The podoplanin-CLEC-2 axis inhibits inflammation in sepsis

Sepsis is a life-threatening condition where exaggerated inflammatory responses lead to severe tissue damage. Here, Rayes and colleagues show that the interaction between podoplanin and its receptor CLEC-2 on platelets plays a critical role in limiting inflammation during sepsis.

Bibliographic Details
Main Authors:	Julie Rayes, Siân Lax, Surasak Wichaiyo, Stephanie K. Watson, Ying Di, Stephanie Lombard, Beata Grygielska, Stuart W. Smith, Kassiani Skordilis, Steve P. Watson
Format:	Article
Language:	English
Published:	Nature Publishing Group 2017-12-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-017-02402-6

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spelling	doaj-b4f263bdafe34009bf6c603e5a0f07a42021-05-11T07:38:38ZengNature Publishing GroupNature Communications2041-17232017-12-018111410.1038/s41467-017-02402-6The podoplanin-CLEC-2 axis inhibits inflammation in sepsisJulie Rayes0Siân Lax1Surasak Wichaiyo2Stephanie K. Watson3Ying Di4Stephanie Lombard5Beata Grygielska6Stuart W. Smith7Kassiani Skordilis8Steve P. Watson9Institute of Cardiovascular Science, College of Medical and Dental Sciences, University of BirminghamInstitute of Cardiovascular Science, College of Medical and Dental Sciences, University of BirminghamInstitute of Cardiovascular Science, College of Medical and Dental Sciences, University of BirminghamInstitute of Cardiovascular Science, College of Medical and Dental Sciences, University of BirminghamInstitute of Cardiovascular Science, College of Medical and Dental Sciences, University of BirminghamInstitute of Cardiovascular Science, College of Medical and Dental Sciences, University of BirminghamInstitute of Cardiovascular Science, College of Medical and Dental Sciences, University of BirminghamDepartment of Renal Medicine, New Queen Elizabeth, Hospital BirminghamDepartment of Cellular Pathology, Queen Elizabeth Hospital BirminghamInstitute of Cardiovascular Science, College of Medical and Dental Sciences, University of BirminghamSepsis is a life-threatening condition where exaggerated inflammatory responses lead to severe tissue damage. Here, Rayes and colleagues show that the interaction between podoplanin and its receptor CLEC-2 on platelets plays a critical role in limiting inflammation during sepsis.https://doi.org/10.1038/s41467-017-02402-6
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Julie Rayes Siân Lax Surasak Wichaiyo Stephanie K. Watson Ying Di Stephanie Lombard Beata Grygielska Stuart W. Smith Kassiani Skordilis Steve P. Watson
spellingShingle	Julie Rayes Siân Lax Surasak Wichaiyo Stephanie K. Watson Ying Di Stephanie Lombard Beata Grygielska Stuart W. Smith Kassiani Skordilis Steve P. Watson The podoplanin-CLEC-2 axis inhibits inflammation in sepsis Nature Communications
author_facet	Julie Rayes Siân Lax Surasak Wichaiyo Stephanie K. Watson Ying Di Stephanie Lombard Beata Grygielska Stuart W. Smith Kassiani Skordilis Steve P. Watson
author_sort	Julie Rayes
title	The podoplanin-CLEC-2 axis inhibits inflammation in sepsis
title_short	The podoplanin-CLEC-2 axis inhibits inflammation in sepsis
title_full	The podoplanin-CLEC-2 axis inhibits inflammation in sepsis
title_fullStr	The podoplanin-CLEC-2 axis inhibits inflammation in sepsis
title_full_unstemmed	The podoplanin-CLEC-2 axis inhibits inflammation in sepsis
title_sort	podoplanin-clec-2 axis inhibits inflammation in sepsis
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2017-12-01
description	Sepsis is a life-threatening condition where exaggerated inflammatory responses lead to severe tissue damage. Here, Rayes and colleagues show that the interaction between podoplanin and its receptor CLEC-2 on platelets plays a critical role in limiting inflammation during sepsis.
url	https://doi.org/10.1038/s41467-017-02402-6
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The podoplanin-CLEC-2 axis inhibits inflammation in sepsis

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