Glycosylation Tunes Neuroserpin Physiological and Pathological Properties

Glycosylation Tunes Neuroserpin Physiological and Pathological Properties

Neuroserpin (NS) is a member of the serine protease inhibitors superfamily. Specific point mutations are responsible for its accumulation in the endoplasmic reticulum of neurons that leads to a pathological condition named familial encephalopathy with neuroserpin inclusion bodies (FENIB). Wild-type...

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Bibliographic Details
Main Authors: Cristina Visentin, Luca Broggini, Benedetta Maria Sala, Rosaria Russo, Alberto Barbiroli, Carlo Santambrogio, Simona Nonnis, Anatoly Dubnovitsky, Martino Bolognesi, Elena Miranda, Adnane Achour, Stefano Ricagno
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:International Journal of Molecular Sciences
Subjects:
neuroserpin
protein polymerisation
glycosylation
Online Access:https://www.mdpi.com/1422-0067/21/9/3235

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