Association between gene expression profiles and clinical outcome of pemetrexed-based treatment in patients with advanced non-squamous non-small cell lung cancer: exploratory results from a phase II study.

Association between gene expression profiles and clinical outcome of pemetrexed-based treatment in patients with advanced non-squamous non-small cell lung cancer: exploratory results from a phase II study.

We report exploratory gene-expression profiling data from a single-arm Phase-II-study in patients with non-squamous (ns)NSCLC treated with pemetrexed and cisplatin. Previously disclosed results indicated a significant association of low thymidylate-synthase (TS)-expression with longer progression-fr...

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Bibliographic Details
Main Authors: Dean A Fennell, Scott P Myrand, Tuan S Nguyen, David Ferry, Keith M Kerr, Perry Maxwell, Stephen D Moore, Carla Visseren-Grul, Mayukh Das, Marianne C Nicolson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4175467?pdf=render

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http://europepmc.org/articles/PMC4175467?pdf=render

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