Lipid rafts: linking prion protein to zinc transport and amyloid-beta toxicity in Alzheimer’s disease

Dysregulation of neuronal zinc homeostasis plays a major role in many processes related to brain ageing and neurodegenerative diseases, including Alzheimer’s disease (AD). Yet, despite the critical role of zinc in neuronal function, the cellular mechanisms underpinning its homeostatic control are fa...

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Bibliographic Details
Main Authors: Nicole eWatt, Heledd Haf Griffiths, Nigel eHooper
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-08-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fcell.2014.00041/full