Micro-CT analysis of the rodent jaw bone micro-architecture: A systematic review

Introduction: Knowledge about macro- and micro-structural characteristics may improve in vivo estimation of the quality and quantity of regenerated bone tissue. For this reason, micro-CT imaging has been applied to evaluate alveolar bone remodelling, alterations of periodontal ligament thickness and...

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Main Authors: F. Faot, M. Chatterjee, G.V. de Camargos, Joke Duyck, K. Vandamme
Format: Article
Language:English
Published: Elsevier 2015-06-01
Series:Bone Reports
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2352187214000060
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spelling doaj-b4d47af146384be1b7448a34bc3eb6112020-11-24T22:28:10ZengElsevierBone Reports2352-18722015-06-012C142410.1016/j.bonr.2014.10.005Micro-CT analysis of the rodent jaw bone micro-architecture: A systematic reviewF. Faot0M. Chatterjee1G.V. de Camargos2Joke Duyck3K. Vandamme4KU Leuven, University Hospitals Leuven, Department of Oral Health Sciences & Dental Clinic, BIOMAT KU Leuven & Prosthetics, BelgiumKU Leuven, University Hospitals Leuven, Department of Oral Health Sciences & Dental Clinic, BIOMAT KU Leuven & Prosthetics, BelgiumKU Leuven, University Hospitals Leuven, Department of Oral Health Sciences & Dental Clinic, BIOMAT KU Leuven & Prosthetics, BelgiumKU Leuven, University Hospitals Leuven, Department of Oral Health Sciences & Dental Clinic, BIOMAT KU Leuven & Prosthetics, BelgiumKU Leuven, University Hospitals Leuven, Department of Oral Health Sciences & Dental Clinic, BIOMAT KU Leuven & Prosthetics, BelgiumIntroduction: Knowledge about macro- and micro-structural characteristics may improve in vivo estimation of the quality and quantity of regenerated bone tissue. For this reason, micro-CT imaging has been applied to evaluate alveolar bone remodelling, alterations of periodontal ligament thickness and cortical and trabecular bone changes in rodent jaw bones. In this paper, we provide a systematic review on the available micro-CT literature on jaw bone micro-architecture. Methodology: A detailed search through the PubMed database was performed. Articles published up to December 2013 and related to maxilla, mandible and condyle with quantitatively analysed bone micro-architectural parameters were considered eligible for inclusion. Two reviewers assessed the search results according to inclusion criteria designed to identify animal studies quantifying the bone micro-architecture of the jaw rodent bones in physiological or drug-induced disease status, or in response to interventions such as mechanical loading, hormonal treatment and other metabolic alterations. Finally, the reporting quality of the included publications was evaluated using the tailored ARRIVE guidelines outlined by Vignoletti and Abrahamsson (2012). Results: Database search, additional manual searching and assessment of the inclusion and exclusion criteria retrieved 127 potentially relevant articles. Eventually, 14 maxilla, 20 mandible and 12 condyle articles with focus on bone healing were retained, and were analysed together with 3 methodological papers. Each study was described systematically in terms of subject, experimental intervention, follow-up period, selected region of interest used in the micro-CT analysis, parameters quantified, micro-CT scanner device and software. The evidence level evaluated by the ARRIVE guidelines showed high mean scores (between 18 and 25; range: 0–25), indicating that most of the selected studies are well-reported. The major obstacles identified were related to sample size calculation, absence of adverse event descriptions, randomization or blinding procedures. Conclusions: The evaluated studies are highly heterogeneous in terms of research topic and the different regions of interest. These results illustrate the need for a standardized methodology in micro-CT analysis. While the analysed studies do well according to the ARRIVE guidelines, the micro-CT procedure is often insufficiently described. Therefore we recommend to extend the ARRIVE guidelines for micro-CT studies.http://www.sciencedirect.com/science/article/pii/S2352187214000060Bone micro-architectureRodent jawsMaxillaMandibleCondyleMicro-CT
collection DOAJ
language English
format Article
sources DOAJ
author F. Faot
M. Chatterjee
G.V. de Camargos
Joke Duyck
K. Vandamme
spellingShingle F. Faot
M. Chatterjee
G.V. de Camargos
Joke Duyck
K. Vandamme
Micro-CT analysis of the rodent jaw bone micro-architecture: A systematic review
Bone Reports
Bone micro-architecture
Rodent jaws
Maxilla
Mandible
Condyle
Micro-CT
author_facet F. Faot
M. Chatterjee
G.V. de Camargos
Joke Duyck
K. Vandamme
author_sort F. Faot
title Micro-CT analysis of the rodent jaw bone micro-architecture: A systematic review
title_short Micro-CT analysis of the rodent jaw bone micro-architecture: A systematic review
title_full Micro-CT analysis of the rodent jaw bone micro-architecture: A systematic review
title_fullStr Micro-CT analysis of the rodent jaw bone micro-architecture: A systematic review
title_full_unstemmed Micro-CT analysis of the rodent jaw bone micro-architecture: A systematic review
title_sort micro-ct analysis of the rodent jaw bone micro-architecture: a systematic review
publisher Elsevier
series Bone Reports
issn 2352-1872
publishDate 2015-06-01
description Introduction: Knowledge about macro- and micro-structural characteristics may improve in vivo estimation of the quality and quantity of regenerated bone tissue. For this reason, micro-CT imaging has been applied to evaluate alveolar bone remodelling, alterations of periodontal ligament thickness and cortical and trabecular bone changes in rodent jaw bones. In this paper, we provide a systematic review on the available micro-CT literature on jaw bone micro-architecture. Methodology: A detailed search through the PubMed database was performed. Articles published up to December 2013 and related to maxilla, mandible and condyle with quantitatively analysed bone micro-architectural parameters were considered eligible for inclusion. Two reviewers assessed the search results according to inclusion criteria designed to identify animal studies quantifying the bone micro-architecture of the jaw rodent bones in physiological or drug-induced disease status, or in response to interventions such as mechanical loading, hormonal treatment and other metabolic alterations. Finally, the reporting quality of the included publications was evaluated using the tailored ARRIVE guidelines outlined by Vignoletti and Abrahamsson (2012). Results: Database search, additional manual searching and assessment of the inclusion and exclusion criteria retrieved 127 potentially relevant articles. Eventually, 14 maxilla, 20 mandible and 12 condyle articles with focus on bone healing were retained, and were analysed together with 3 methodological papers. Each study was described systematically in terms of subject, experimental intervention, follow-up period, selected region of interest used in the micro-CT analysis, parameters quantified, micro-CT scanner device and software. The evidence level evaluated by the ARRIVE guidelines showed high mean scores (between 18 and 25; range: 0–25), indicating that most of the selected studies are well-reported. The major obstacles identified were related to sample size calculation, absence of adverse event descriptions, randomization or blinding procedures. Conclusions: The evaluated studies are highly heterogeneous in terms of research topic and the different regions of interest. These results illustrate the need for a standardized methodology in micro-CT analysis. While the analysed studies do well according to the ARRIVE guidelines, the micro-CT procedure is often insufficiently described. Therefore we recommend to extend the ARRIVE guidelines for micro-CT studies.
topic Bone micro-architecture
Rodent jaws
Maxilla
Mandible
Condyle
Micro-CT
url http://www.sciencedirect.com/science/article/pii/S2352187214000060
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