Erysacleuxins C and D, new isoflavones from the twigs of Erythrina sacleuxii Hua and their cytotoxic activity

Erysacleuxins C and D, new isoflavones from the twigs of Erythrina sacleuxii Hua and their cytotoxic activity

Two previously undescribed isoflavones, erysacleuxin C (1) and erysacleuxin D (2), together with seven known compounds (3–9), were isolated and identified from the EtOAc extract of the twigs of Erythrina sacleuxii Hua (Leguminosae). The structures of the isolated compounds were determined on the bas...

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Main Authors: Japheth O. Ombito, Gomotsang Bojase, Runner R.T. Majinda, Ishmael B. Masesane, Anja Schüffler, Till Opatz
Format: Article
Language:English
Published: Elsevier 2020-02-01
Series:Arabian Journal of Chemistry
Online Access:http://www.sciencedirect.com/science/article/pii/S187853521930053X
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spelling doaj-b4ce727a77bd49b5a0b5a6c4c9a677962020-11-25T02:11:36ZengElsevierArabian Journal of Chemistry1878-53522020-02-0113240194023Erysacleuxins C and D, new isoflavones from the twigs of Erythrina sacleuxii Hua and their cytotoxic activityJapheth O. Ombito0Gomotsang Bojase1Runner R.T. Majinda2Ishmael B. Masesane3Anja Schüffler4Till Opatz5Department of Chemistry, University of Botswana, Private Bag 0022, Gaborone, Botswana; Corresponding author.Department of Chemistry, University of Botswana, Private Bag 0022, Gaborone, BotswanaDepartment of Chemistry, University of Botswana, Private Bag 0022, Gaborone, BotswanaDepartment of Chemistry, University of Botswana, Private Bag 0022, Gaborone, BotswanaInstitut für Biotechnologie und Wirkstoff-Forschung gGmbH, Erwin-Schrödinger-Straße 56, D-67663 Kaiserslautern, GermanyJohannes Gutenberg University Mainz, Institute of Organic Chemistry, Duesbergweg 10–14, D-55128 Mainz, GermanyTwo previously undescribed isoflavones, erysacleuxin C (1) and erysacleuxin D (2), together with seven known compounds (3–9), were isolated and identified from the EtOAc extract of the twigs of Erythrina sacleuxii Hua (Leguminosae). The structures of the isolated compounds were determined on the basis of their spectroscopic and spectrometric data. Evaluation of their cytotoxicity against the human cancer HeLa-S3 cell lines indicated IC50 values of 130.4, 54.9 and 73.9 µM for erysacleuxin C (1), erysacleuxin D (2) and butin (9), respectively. Keywords: Erythrina sacleuxii, Leguminosae, Isoflavone, Erysacleuxin C, Erysacleuxin D, Cytotoxicityhttp://www.sciencedirect.com/science/article/pii/S187853521930053X
collection DOAJ
language English
format Article
sources DOAJ
author Japheth O. Ombito
Gomotsang Bojase
Runner R.T. Majinda
Ishmael B. Masesane
Anja Schüffler
Till Opatz
spellingShingle Japheth O. Ombito
Gomotsang Bojase
Runner R.T. Majinda
Ishmael B. Masesane
Anja Schüffler
Till Opatz
Erysacleuxins C and D, new isoflavones from the twigs of Erythrina sacleuxii Hua and their cytotoxic activity
Arabian Journal of Chemistry
author_facet Japheth O. Ombito
Gomotsang Bojase
Runner R.T. Majinda
Ishmael B. Masesane
Anja Schüffler
Till Opatz
author_sort Japheth O. Ombito
title Erysacleuxins C and D, new isoflavones from the twigs of Erythrina sacleuxii Hua and their cytotoxic activity
title_short Erysacleuxins C and D, new isoflavones from the twigs of Erythrina sacleuxii Hua and their cytotoxic activity
title_full Erysacleuxins C and D, new isoflavones from the twigs of Erythrina sacleuxii Hua and their cytotoxic activity
title_fullStr Erysacleuxins C and D, new isoflavones from the twigs of Erythrina sacleuxii Hua and their cytotoxic activity
title_full_unstemmed Erysacleuxins C and D, new isoflavones from the twigs of Erythrina sacleuxii Hua and their cytotoxic activity
title_sort erysacleuxins c and d, new isoflavones from the twigs of erythrina sacleuxii hua and their cytotoxic activity
publisher Elsevier
series Arabian Journal of Chemistry
issn 1878-5352
publishDate 2020-02-01
description Two previously undescribed isoflavones, erysacleuxin C (1) and erysacleuxin D (2), together with seven known compounds (3–9), were isolated and identified from the EtOAc extract of the twigs of Erythrina sacleuxii Hua (Leguminosae). The structures of the isolated compounds were determined on the basis of their spectroscopic and spectrometric data. Evaluation of their cytotoxicity against the human cancer HeLa-S3 cell lines indicated IC50 values of 130.4, 54.9 and 73.9 µM for erysacleuxin C (1), erysacleuxin D (2) and butin (9), respectively. Keywords: Erythrina sacleuxii, Leguminosae, Isoflavone, Erysacleuxin C, Erysacleuxin D, Cytotoxicity
url http://www.sciencedirect.com/science/article/pii/S187853521930053X
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