Identification of optimal fluorescent probes for G-quadruplex nucleic acids through systematic exploration of mono- and distyryl dye libraries

Identification of optimal fluorescent probes for G-quadruplex nucleic acids through systematic exploration of mono- and distyryl dye libraries

A library of 52 distyryl and 9 mono-styryl cationic dyes was synthesized and investigated with respect to their optical properties, propensity to aggregation in aqueous medium, and capacity to serve as fluorescence “light-up” probes for G-quadruplex (G4) DNA and RNA structures. Among the 61 compound...

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Bibliographic Details
Main Authors: Xiao Xie, Michela Zuffo, Marie-Paule Teulade-Fichou, Anton Granzhan
Format: Article
Language:English
Published: Beilstein-Institut 2019-08-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
fluorescent probes
G-quadruplex DNA
G-quadruplex RNA
nucleic acids
styryl dyes
Online Access:https://doi.org/10.3762/bjoc.15.183

Internet

https://doi.org/10.3762/bjoc.15.183

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