Modification of superoxide dismutase 1 (SOD1) properties by a GFP tag--implications for research into amyotrophic lateral sclerosis (ALS).

Modification of superoxide dismutase 1 (SOD1) properties by a GFP tag--implications for research into amyotrophic lateral sclerosis (ALS).

Since the discovery that mutations in the enzyme SOD1 are causative in human amyotrophic lateral sclerosis (ALS), many strategies have been employed to elucidate the toxic properties of this ubiquitously expressed mutant protein, including the generation of GFP-SOD1 chimaeric proteins for studies in...

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Bibliographic Details
Main Authors: James C Stevens, Ruth Chia, William T Hendriks, Virginie Bros-Facer, Jan van Minnen, Joanne E Martin, Graham S Jackson, Linda Greensmith, Giampietro Schiavo, Elizabeth M C Fisher
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-03-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2833207?pdf=render

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http://europepmc.org/articles/PMC2833207?pdf=render

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