Microbiological Synthesis of 2H-Labeled Phenylalanine, Alanine, Valine, and Leucine/Isoleucine with Different Degrees of Deuterium Enrichment by the Gram-Positive Facultative Methylotrophic Bacterium Вrevibacterium Methylicum

Microbiological Synthesis of 2H-Labeled Phenylalanine, Alanine, Valine, and Leucine/Isoleucine with Different Degrees of Deuterium Enrichment by the Gram-Positive Facultative Methylotrophic Bacterium Вrevibacterium Methylicum

The microbiological synthesis of [2H]amino acids was performed by the conversion of low molecular weight substrates ([U-2H]MeOH and 2H2O) using the Gram-positive aerobic facultative methylotrophic bacterium Brevibacterium methylicum, an L-phenylalanine producer, realizing the NAD+ dependent methano...

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Bibliographic Details
Main Authors: Oleg V. Mosin, PhD¹, Ignat Ignatov, ScD²
Format: Article
Language:English
Published: International Medical Research and Development Corporation 2013-06-01
Series:International Journal of Biomedicine
Subjects:
[2H]amino acids
biosynthesis
Brevibacterium methylicum
EI mass spectrometry
heavy water
[U-2H]methanol
Online Access:http://www.ijbm.org/articles/3_2_Biotech1.pdf

Internet

http://www.ijbm.org/articles/3_2_Biotech1.pdf

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