Radiation-induced DNA damage and repair effects on 3D genome organization

Radiation-induced DNA damage and repair effects on 3D genome organization

Genomic aberrations disrupting chromosome spatial domains can lead to disease. Here, the authors investigate the impact of DNA damage response and repair on 3D genome folding, comparing wild type cells and ataxia telangiectasia mutated patient cells, and characterise both cell type-specific and shar...

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Bibliographic Details
Main Authors: Jacob T. Sanders, Trevor F. Freeman, Yang Xu, Rosela Golloshi, Mary A. Stallard, Ashtyn M. Hill, Rebeca San Martin, Adayabalam S. Balajee, Rachel Patton McCord
Format: Article
Language:English
Published: Nature Publishing Group 2020-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-20047-w

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