Glioblastoma stem cell (GSC)-derived PD-L1-containing exosomes activates AMPK/ULK1 pathway mediated autophagy to increase temozolomide-resistance in glioblastoma

Glioblastoma stem cell (GSC)-derived PD-L1-containing exosomes activates AMPK/ULK1 pathway mediated autophagy to increase temozolomide-resistance in glioblastoma

Abstract Temozolomide (TMZ)-resistance hampers the therapeutic efficacy of this drug for glioblastoma (GBM) treatment in clinic, and emerging evidences suggested that exosomes from GBM-derived stem cells (GSCs) contributed to this process, but the detailed mechanisms are still largely unknown. In th...

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Bibliographic Details
Main Authors: Yong Zheng, Liang Liu, Yan Wang, Shan Xiao, Rongkang Mai, Zifeng Zhu, Yiyao Cao
Format: Article
Language:English
Published: BMC 2021-03-01
Series:Cell & Bioscience
Subjects:
Glioblastoma
GBM-derived stem cells
Temozolomide
Programmed death-ligand 1
Autophagy
Online Access:https://doi.org/10.1186/s13578-021-00575-8

Internet

https://doi.org/10.1186/s13578-021-00575-8

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