Nanoscale metal-organic frameworks for mitochondria-targeted radiotherapy-radiodynamic therapy

Nanoscale metal-organic frameworks for mitochondria-targeted radiotherapy-radiodynamic therapy

Photosensitizers delivered to mitochondria of cancer cells can enhance photodynamic therapy. Here, the authors report mitochondria-targeted radiation therapy and radiodynamic therapy of colorectal cancer models with a cationic nanoscale metal-organic framework to overcome shallow light penetration o...

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Main Authors: Kaiyuan Ni, Guangxu Lan, Samuel S. Veroneau, Xiaopin Duan, Yang Song, Wenbin Lin
Format: Article
Language:English
Published: Nature Publishing Group 2018-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-06655-7
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spelling doaj-b48e9debae774852a0d394aca21414372021-05-11T10:26:24ZengNature Publishing GroupNature Communications2041-17232018-10-019111310.1038/s41467-018-06655-7Nanoscale metal-organic frameworks for mitochondria-targeted radiotherapy-radiodynamic therapyKaiyuan Ni0Guangxu Lan1Samuel S. Veroneau2Xiaopin Duan3Yang Song4Wenbin Lin5Department of Chemistry, The University of ChicagoDepartment of Chemistry, The University of ChicagoDepartment of Chemistry, The University of ChicagoDepartment of Chemistry, The University of ChicagoDepartment of Chemistry, The University of ChicagoDepartment of Chemistry, The University of ChicagoPhotosensitizers delivered to mitochondria of cancer cells can enhance photodynamic therapy. Here, the authors report mitochondria-targeted radiation therapy and radiodynamic therapy of colorectal cancer models with a cationic nanoscale metal-organic framework to overcome shallow light penetration of Ru-based photosensitizers.https://doi.org/10.1038/s41467-018-06655-7
collection DOAJ
language English
format Article
sources DOAJ
author Kaiyuan Ni
Guangxu Lan
Samuel S. Veroneau
Xiaopin Duan
Yang Song
Wenbin Lin
spellingShingle Kaiyuan Ni
Guangxu Lan
Samuel S. Veroneau
Xiaopin Duan
Yang Song
Wenbin Lin
Nanoscale metal-organic frameworks for mitochondria-targeted radiotherapy-radiodynamic therapy
Nature Communications
author_facet Kaiyuan Ni
Guangxu Lan
Samuel S. Veroneau
Xiaopin Duan
Yang Song
Wenbin Lin
author_sort Kaiyuan Ni
title Nanoscale metal-organic frameworks for mitochondria-targeted radiotherapy-radiodynamic therapy
title_short Nanoscale metal-organic frameworks for mitochondria-targeted radiotherapy-radiodynamic therapy
title_full Nanoscale metal-organic frameworks for mitochondria-targeted radiotherapy-radiodynamic therapy
title_fullStr Nanoscale metal-organic frameworks for mitochondria-targeted radiotherapy-radiodynamic therapy
title_full_unstemmed Nanoscale metal-organic frameworks for mitochondria-targeted radiotherapy-radiodynamic therapy
title_sort nanoscale metal-organic frameworks for mitochondria-targeted radiotherapy-radiodynamic therapy
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2018-10-01
description Photosensitizers delivered to mitochondria of cancer cells can enhance photodynamic therapy. Here, the authors report mitochondria-targeted radiation therapy and radiodynamic therapy of colorectal cancer models with a cationic nanoscale metal-organic framework to overcome shallow light penetration of Ru-based photosensitizers.
url https://doi.org/10.1038/s41467-018-06655-7
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AT guangxulan nanoscalemetalorganicframeworksformitochondriatargetedradiotherapyradiodynamictherapy
AT samuelsveroneau nanoscalemetalorganicframeworksformitochondriatargetedradiotherapyradiodynamictherapy
AT xiaopinduan nanoscalemetalorganicframeworksformitochondriatargetedradiotherapyradiodynamictherapy
AT yangsong nanoscalemetalorganicframeworksformitochondriatargetedradiotherapyradiodynamictherapy
AT wenbinlin nanoscalemetalorganicframeworksformitochondriatargetedradiotherapyradiodynamictherapy
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