The ups and downs of mutation frequencies during aging can account for the Apert syndrome paternal age effect.

Apert syndrome is almost always caused by a spontaneous mutation of paternal origin in one of two nucleotides in the fibroblast growth factor receptor 2 gene (FGFR2). The incidence of this disease increases with the age of the father (paternal age effect), and this increase is greater than what woul...

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Bibliographic Details
Main Authors: Song-Ro Yoon, Jian Qin, Rivka L Glaser, Ethylin Wang Jabs, Nancy S Wexler, Rebecca Sokol, Norman Arnheim, Peter Calabrese
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-07-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC2700275?pdf=render