The ups and downs of mutation frequencies during aging can account for the Apert syndrome paternal age effect.
Apert syndrome is almost always caused by a spontaneous mutation of paternal origin in one of two nucleotides in the fibroblast growth factor receptor 2 gene (FGFR2). The incidence of this disease increases with the age of the father (paternal age effect), and this increase is greater than what woul...
Main Authors: | , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2009-07-01
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Series: | PLoS Genetics |
Online Access: | http://europepmc.org/articles/PMC2700275?pdf=render |