Estimating fetal exposure to the P‐gp substrates, corticosteroids, by PBPK modeling to inform prevention of neonatal respiratory distress syndrome

Estimating fetal exposure to the P‐gp substrates, corticosteroids, by PBPK modeling to inform prevention of neonatal respiratory distress syndrome

Abstract We have previously developed a maternal‐fetal physiologically‐based pharmacokinetic (m‐f PBPK) model to dynamically predict (and verify) fetal‐maternal exposure to drugs that passively diffuse across the placenta. Here, we extended the application of this model to dynamically predict fetal...

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Bibliographic Details
Main Authors: Olena Anoshchenko, Mark A. Milad, Jashvant D. Unadkat
Format: Article
Language:English
Published: Wiley 2021-09-01
Series:CPT: Pharmacometrics & Systems Pharmacology
Online Access:https://doi.org/10.1002/psp4.12674

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