A proline-rich motif in the large intracellular loop of the glycine receptor α1 subunit interacts with the Pleckstrin homology domain of collybistin

A proline-rich motif in the large intracellular loop of the glycine receptor α1 subunit interacts with the Pleckstrin homology domain of collybistin

Introduction: The inhibitory glycine receptor (GlyR), a mediator of fast synaptic inhibition, is located and held at neuronal synapses through the anchoring proteins gephyrin and collybistin. Stable localization of neurotransmitter receptors is essential for synaptic function. In case of GlyRs, only...

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Bibliographic Details
Main Authors: Ulrike Breitinger, Kristina Weinländer, Yvonne Pechmann, Georg Langlhofer, Ralf Enz, Cord-Michael Becker, Heinrich Sticht, Matthias Kneussel, Carmen Villmann, Hans-Georg Breitinger
Format: Article
Language:English
Published: Elsevier 2021-03-01
Series:Journal of Advanced Research
Subjects:
Ion channel receptors
Synaptic anchoring
Protein-protein interaction
Glycine receptor alpha1 subunit
Polyproline II helix
Collybistin
Online Access:http://www.sciencedirect.com/science/article/pii/S2090123220302198

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