ON THE ISSUE OF PROTEIN C SYSTEM DISORDERS IN PREGNANT WOMEN WITH VARIOUS OBSTETRIC PATHOLOGY IN PAST HISTORY

ON THE ISSUE OF PROTEIN C SYSTEM DISORDERS IN PREGNANT WOMEN WITH VARIOUS OBSTETRIC PATHOLOGY IN PAST HISTORY

This article is focused on the pathophysiology, prevalence , clinical manifestations, diagnosis, and treatment C deficiency with increased risk of thrombosis. Activated protein C (aPC) exerts its anticoagulant activity through inactivation of coagulation factors Va and VIIIa. Aside its anticoagulant...

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Main Author: I. A. Mikhaylidi
Format: Article
Language:Russian
Published: IRBIS LLC 2016-06-01
Series:Акушерство, гинекология и репродукция
Subjects:
activated protein c
aps resistance
factor v leiden mutation
thromboses
endothelial protein c receptor
Online Access:https://www.gynecology.su/jour/article/view/82
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spelling doaj-b48260c6a80f471bad7921eef5fcec732021-07-28T13:44:37ZrusIRBIS LLCАкушерство, гинекология и репродукция2313-73472500-31942016-06-0183596480ON THE ISSUE OF PROTEIN C SYSTEM DISORDERS IN PREGNANT WOMEN WITH VARIOUS OBSTETRIC PATHOLOGY IN PAST HISTORYI. A. Mikhaylidi0The State Education Institution of Higher Professional Training The First Sechenov Moscow State Medical University under Ministry of Health of the Russian FederationThis article is focused on the pathophysiology, prevalence , clinical manifestations, diagnosis, and treatment C deficiency with increased risk of thrombosis. Activated protein C (aPC) exerts its anticoagulant activity through inactivation of coagulation factors Va and VIIIa. Aside its anticoagulant property, aPC demonstrates anti-inflammatory and cytoprotectiveeffects, which are mediated through the endothelial protein C receptor and the protease-activated receptor-I (PAR-1). Studying and understanding the biological function of APS makes it possible to control coagulation and inflammation and to apply protein C preparations as anticoagulant and cytoprotective drugs in a physicians clinicalpractice.https://www.gynecology.su/jour/article/view/82activated protein caps resistancefactor v leiden mutationthrombosesendothelial protein c receptor
collection DOAJ
language Russian
format Article
sources DOAJ
author I. A. Mikhaylidi
spellingShingle I. A. Mikhaylidi
ON THE ISSUE OF PROTEIN C SYSTEM DISORDERS IN PREGNANT WOMEN WITH VARIOUS OBSTETRIC PATHOLOGY IN PAST HISTORY
Акушерство, гинекология и репродукция
activated protein c
aps resistance
factor v leiden mutation
thromboses
endothelial protein c receptor
author_facet I. A. Mikhaylidi
author_sort I. A. Mikhaylidi
title ON THE ISSUE OF PROTEIN C SYSTEM DISORDERS IN PREGNANT WOMEN WITH VARIOUS OBSTETRIC PATHOLOGY IN PAST HISTORY
title_short ON THE ISSUE OF PROTEIN C SYSTEM DISORDERS IN PREGNANT WOMEN WITH VARIOUS OBSTETRIC PATHOLOGY IN PAST HISTORY
title_full ON THE ISSUE OF PROTEIN C SYSTEM DISORDERS IN PREGNANT WOMEN WITH VARIOUS OBSTETRIC PATHOLOGY IN PAST HISTORY
title_fullStr ON THE ISSUE OF PROTEIN C SYSTEM DISORDERS IN PREGNANT WOMEN WITH VARIOUS OBSTETRIC PATHOLOGY IN PAST HISTORY
title_full_unstemmed ON THE ISSUE OF PROTEIN C SYSTEM DISORDERS IN PREGNANT WOMEN WITH VARIOUS OBSTETRIC PATHOLOGY IN PAST HISTORY
title_sort on the issue of protein c system disorders in pregnant women with various obstetric pathology in past history
publisher IRBIS LLC
series Акушерство, гинекология и репродукция
issn 2313-7347
2500-3194
publishDate 2016-06-01
description This article is focused on the pathophysiology, prevalence , clinical manifestations, diagnosis, and treatment C deficiency with increased risk of thrombosis. Activated protein C (aPC) exerts its anticoagulant activity through inactivation of coagulation factors Va and VIIIa. Aside its anticoagulant property, aPC demonstrates anti-inflammatory and cytoprotectiveeffects, which are mediated through the endothelial protein C receptor and the protease-activated receptor-I (PAR-1). Studying and understanding the biological function of APS makes it possible to control coagulation and inflammation and to apply protein C preparations as anticoagulant and cytoprotective drugs in a physicians clinicalpractice.
topic activated protein c
aps resistance
factor v leiden mutation
thromboses
endothelial protein c receptor
url https://www.gynecology.su/jour/article/view/82
work_keys_str_mv AT iamikhaylidi ontheissueofproteincsystemdisordersinpregnantwomenwithvariousobstetricpathologyinpasthistory
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