Genomic heterogeneity of multiple synchronous lung cancer
Some patients present with multiple lung tumours but it is unclear whether these are metastases or individual lesions. Here, the authors use genomics techniques to demonstrate in six patients that multiple tumours have individual genetic profiles and represent separate tumours.
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2016-10-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms13200 |
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DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Yu Liu Jianjun Zhang Lin Li Guangliang Yin Jianhua Zhang Shan Zheng Hannah Cheung Ning Wu Ning Lu Xizeng Mao Longhai Yang Jiexin Zhang Li Zhang Sahil Seth Huang Chen Xingzhi Song Kan Liu Yongqiang Xie Lina Zhou Chuanduo Zhao Naijun Han Wenting Chen Susu Zhang Longyun Chen Wenjun Cai Lin Li Miaozhong Shen Ningzhi Xu Shujun Cheng Huanming Yang J. Jack Lee Arlene Correa Junya Fujimoto Carmen Behrens Chi-Wan Chow William N. William John V. Heymach Waun Ki Hong Stephen Swisher Ignacio I. Wistuba Jun Wang Dongmei Lin Xiangyang Liu P. Andrew Futreal Yanning Gao |
| spellingShingle |
Yu Liu Jianjun Zhang Lin Li Guangliang Yin Jianhua Zhang Shan Zheng Hannah Cheung Ning Wu Ning Lu Xizeng Mao Longhai Yang Jiexin Zhang Li Zhang Sahil Seth Huang Chen Xingzhi Song Kan Liu Yongqiang Xie Lina Zhou Chuanduo Zhao Naijun Han Wenting Chen Susu Zhang Longyun Chen Wenjun Cai Lin Li Miaozhong Shen Ningzhi Xu Shujun Cheng Huanming Yang J. Jack Lee Arlene Correa Junya Fujimoto Carmen Behrens Chi-Wan Chow William N. William John V. Heymach Waun Ki Hong Stephen Swisher Ignacio I. Wistuba Jun Wang Dongmei Lin Xiangyang Liu P. Andrew Futreal Yanning Gao Genomic heterogeneity of multiple synchronous lung cancer Nature Communications |
| author_facet |
Yu Liu Jianjun Zhang Lin Li Guangliang Yin Jianhua Zhang Shan Zheng Hannah Cheung Ning Wu Ning Lu Xizeng Mao Longhai Yang Jiexin Zhang Li Zhang Sahil Seth Huang Chen Xingzhi Song Kan Liu Yongqiang Xie Lina Zhou Chuanduo Zhao Naijun Han Wenting Chen Susu Zhang Longyun Chen Wenjun Cai Lin Li Miaozhong Shen Ningzhi Xu Shujun Cheng Huanming Yang J. Jack Lee Arlene Correa Junya Fujimoto Carmen Behrens Chi-Wan Chow William N. William John V. Heymach Waun Ki Hong Stephen Swisher Ignacio I. Wistuba Jun Wang Dongmei Lin Xiangyang Liu P. Andrew Futreal Yanning Gao |
| author_sort |
Yu Liu |
| title |
Genomic heterogeneity of multiple synchronous lung cancer |
| title_short |
Genomic heterogeneity of multiple synchronous lung cancer |
| title_full |
Genomic heterogeneity of multiple synchronous lung cancer |
| title_fullStr |
Genomic heterogeneity of multiple synchronous lung cancer |
| title_full_unstemmed |
Genomic heterogeneity of multiple synchronous lung cancer |
| title_sort |
genomic heterogeneity of multiple synchronous lung cancer |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2016-10-01 |
| description |
Some patients present with multiple lung tumours but it is unclear whether these are metastases or individual lesions. Here, the authors use genomics techniques to demonstrate in six patients that multiple tumours have individual genetic profiles and represent separate tumours. |
| url |
https://doi.org/10.1038/ncomms13200 |
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1721447223277912064 |
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doaj-b47899a5b32046278f07cf214de45ffc2021-05-11T10:59:38ZengNature Publishing GroupNature Communications2041-17232016-10-01711810.1038/ncomms13200Genomic heterogeneity of multiple synchronous lung cancerYu Liu0Jianjun Zhang1Lin Li2Guangliang Yin3Jianhua Zhang4Shan Zheng5Hannah Cheung6Ning Wu7Ning Lu8Xizeng Mao9Longhai Yang10Jiexin Zhang11Li Zhang12Sahil Seth13Huang Chen14Xingzhi Song15Kan Liu16Yongqiang Xie17Lina Zhou18Chuanduo Zhao19Naijun Han20Wenting Chen21Susu Zhang22Longyun Chen23Wenjun Cai24Lin Li25Miaozhong Shen26Ningzhi Xu27Shujun Cheng28Huanming Yang29J. Jack Lee30Arlene Correa31Junya Fujimoto32Carmen Behrens33Chi-Wan Chow34William N. William35John V. Heymach36Waun Ki Hong37Stephen Swisher38Ignacio I. Wistuba39Jun Wang40Dongmei Lin41Xiangyang Liu42P. Andrew Futreal43Yanning Gao44Department of Etiology and Carcinogenesis, State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Peking Union Medical College and Chinese Academy of Medical SciencesDepartment of Genomic Medicine, The University of Texas MD Anderson Cancer CenterDepartment of Etiology and Carcinogenesis, State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Peking Union Medical College and Chinese Academy of Medical SciencesBeijing Genomics InstituteInstitute for Applied Cancer Science, The University of Texas MD Anderson Cancer CenterDepartment of Pathology, Cancer Institute and Hospital, Peking Union Medical College and Chinese Academy of Medical SciencesDepartment of Genomic Medicine, The University of Texas MD Anderson Cancer CenterDepartment of Diagnostic Imaging, Cancer Institute and Hospital, Peking Union Medical College and Chinese Academy of Medical SciencesDepartment of Pathology, Cancer Institute and Hospital, Peking Union Medical College and Chinese Academy of Medical SciencesInstitute for Applied Cancer Science, The University of Texas MD Anderson Cancer CenterDepartment of Thoracic Surgical Oncology, Cancer Institute and Hospital, Peking Union Medical College and Chinese Academy of Medical SciencesDepartment of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer CenterDepartment of Diagnostic Imaging, Cancer Institute and Hospital, Peking Union Medical College and Chinese Academy of Medical SciencesInstitute for Applied Cancer Science, The University of Texas MD Anderson Cancer CenterDepartment of Etiology and Carcinogenesis, State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Peking Union Medical College and Chinese Academy of Medical SciencesInstitute for Applied Cancer Science, The University of Texas MD Anderson Cancer CenterDepartment of Diagnostic Imaging, Cancer Institute and Hospital, Peking Union Medical College and Chinese Academy of Medical SciencesDepartment of Pathology, Cancer Institute and Hospital, Peking Union Medical College and Chinese Academy of Medical SciencesDepartment of Diagnostic Imaging, Cancer Institute and Hospital, Peking Union Medical College and Chinese Academy of Medical SciencesDepartment of Thoracic Surgical Oncology, Cancer Institute and Hospital, Peking Union Medical College and Chinese Academy of Medical SciencesDepartment of Etiology and Carcinogenesis, State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Peking Union Medical College and Chinese Academy of Medical SciencesDepartment of Etiology and Carcinogenesis, State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Peking Union Medical College and Chinese Academy of Medical SciencesDepartment of Etiology and Carcinogenesis, State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Peking Union Medical College and Chinese Academy of Medical SciencesBeijing Genomics InstituteBeijing Genomics InstituteBeijing Genomics InstituteBeijing Genomics InstituteDepartment of Cellular and Molecular Biology, State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Peking Union Medical College and Chinese Academy of Medical SciencesDepartment of Etiology and Carcinogenesis, State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Peking Union Medical College and Chinese Academy of Medical SciencesBeijing Genomics InstituteDepartment of Biostatistics, The University of Texas MD Anderson Cancer CenterDepartment of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer CenterDepartment of Translational Molecular Pathology, The University of Texas MD Anderson Cancer CenterDepartment of Translational Molecular Pathology, The University of Texas MD Anderson Cancer CenterDepartment of Translational Molecular Pathology, The University of Texas MD Anderson Cancer CenterDepartment of Thoracic/Head & Neck Medical Oncology, The University of Texas MD Anderson Cancer CenterDepartment of Thoracic/Head & Neck Medical Oncology, The University of Texas MD Anderson Cancer CenterDepartment of Thoracic/Head & Neck Medical Oncology, The University of Texas MD Anderson Cancer CenterDepartment of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer CenterDepartment of Translational Molecular Pathology, The University of Texas MD Anderson Cancer CenterBeijing Genomics InstituteDepartment of Pathology, Cancer Institute and Hospital, Peking Union Medical College and Chinese Academy of Medical SciencesDepartment of Thoracic Surgical Oncology, Cancer Institute and Hospital, Peking Union Medical College and Chinese Academy of Medical SciencesDepartment of Genomic Medicine, The University of Texas MD Anderson Cancer CenterDepartment of Etiology and Carcinogenesis, State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Peking Union Medical College and Chinese Academy of Medical SciencesSome patients present with multiple lung tumours but it is unclear whether these are metastases or individual lesions. Here, the authors use genomics techniques to demonstrate in six patients that multiple tumours have individual genetic profiles and represent separate tumours.https://doi.org/10.1038/ncomms13200 |