Lower affinity T cells are critical components and active participants of the immune response

Lower affinity T cells are critical components and active participants of the immune response

Kinetic and biophysical parameters of T cell receptor (TCR) and peptide:MHC (pMHC) interaction define intrinsic factors required for T cell activation and differentiation. Although receptor ligand kinetics are somewhat cumbersome to assess experimentally, TCR:pMHC affinity has been shown to predict...

Full description

Bibliographic Details
Main Authors: Ryan eMartinez, Brian eEvavold
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-09-01
Series:Frontiers in Immunology
Subjects:
T cells
Tetramers
2D assays
TCR Affinity
T cell diversity
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00468/full

Similar Items

Similar Items