Caspase-11 Controls Interleukin-1β Release through Degradation of TRPC1

Caspase-11 Controls Interleukin-1β Release through Degradation of TRPC1

Caspase-11 is a highly inducible caspase that controls both inflammatory responses and cell death. Caspase-11 controls interleukin 1β (IL-1β) secretion by potentiating caspase-1 activation and induces caspase-1-independent pyroptosis downstream of noncanonical NLRP3 inflammasome activators such as l...

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Bibliographic Details
Main Authors: Bénédicte F. Py, Mingzhi Jin, Bimal N. Desai, Anirudh Penumaka, Hong Zhu, Maike Kober, Alexander Dietrich, Marta M. Lipinski, Thomas Henry, David E. Clapham, Junying Yuan
Format: Article
Language:English
Published: Elsevier 2014-03-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124714001156

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http://www.sciencedirect.com/science/article/pii/S2211124714001156

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