Moderate Physical Activity as a Prevention Method for Knee Osteoarthritis and the Role of Synoviocytes as Biological Key

The purpose of this study was to investigate the influence of moderate physical activity (MPA) on the expression of osteoarthritis (OA)-related (IL-1β, IL-6, TNF-α, MMP-13) and anti-inflammatory and chondroprotective (IL-4, IL-10, lubricin) biomarkers in the synovium of an OA-induc...

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Main Authors: Paola Castrogiovanni, Michelino Di Rosa, Silvia Ravalli, Alessandro Castorina, Claudia Guglielmino, Rosa Imbesi, Michele Vecchio, Filippo Drago, Marta Anna Szychlinska, Giuseppe Musumeci
Format: Article
Language:English
Published: MDPI AG 2019-01-01
Series:International Journal of Molecular Sciences
Subjects:
Online Access:https://www.mdpi.com/1422-0067/20/3/511
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spelling doaj-b4462d4b15524d808eda66f834c4abd52020-11-25T01:01:04ZengMDPI AGInternational Journal of Molecular Sciences1422-00672019-01-0120351110.3390/ijms20030511ijms20030511Moderate Physical Activity as a Prevention Method for Knee Osteoarthritis and the Role of Synoviocytes as Biological KeyPaola Castrogiovanni0Michelino Di Rosa1Silvia Ravalli2Alessandro Castorina3Claudia Guglielmino4Rosa Imbesi5Michele Vecchio6Filippo Drago7Marta Anna Szychlinska8Giuseppe Musumeci9Department of Biomedical and Biotechnological Sciences, Human Anatomy and Histology Section, School of Medicine, University of Catania, Via S. Sofia n°87, 95124 Catania, ItalyDepartment of Biomedical and Biotechnological Sciences, Human Anatomy and Histology Section, School of Medicine, University of Catania, Via S. Sofia n°87, 95124 Catania, ItalyDepartment of Biomedical and Biotechnological Sciences, Human Anatomy and Histology Section, School of Medicine, University of Catania, Via S. Sofia n°87, 95124 Catania, ItalySchool of Life Sciences, Faculty of Science, University of Technology Sydney, P.O. Box 123, Broadway, Sydney, NSW 2007, AustraliaDepartment of Biomedical and Biotechnological Sciences, Human Anatomy and Histology Section, School of Medicine, University of Catania, Via S. Sofia n°87, 95124 Catania, ItalyDepartment of Biomedical and Biotechnological Sciences, Human Anatomy and Histology Section, School of Medicine, University of Catania, Via S. Sofia n°87, 95124 Catania, ItalyDepartment of Biomedical and Biotechnological Sciences, Section of Pharmacology, University of Catania, via S. Sofia 67, 95123 Catania, ItalyDepartment of Biomedical and Biotechnological Sciences, Section of Pharmacology, University of Catania, via S. Sofia 67, 95123 Catania, ItalyDepartment of Biomedical and Biotechnological Sciences, Human Anatomy and Histology Section, School of Medicine, University of Catania, Via S. Sofia n°87, 95124 Catania, ItalyDepartment of Biomedical and Biotechnological Sciences, Human Anatomy and Histology Section, School of Medicine, University of Catania, Via S. Sofia n°87, 95124 Catania, ItalyThe purpose of this study was to investigate the influence of moderate physical activity (MPA) on the expression of osteoarthritis (OA)-related (IL-1β, IL-6, TNF-α, MMP-13) and anti-inflammatory and chondroprotective (IL-4, IL-10, lubricin) biomarkers in the synovium of an OA-induced rat model. A total of 32 rats were divided into four groups: Control rats (Group 1); rats performing MPA (Group 2); anterior cruciate ligament transection (ACLT)-rats with OA (Group 3); and, ACLT-rats performing MPA (Group 4). Analyses were performed using Hematoxylin & Eosin (H&E) staining, histomorphometry and immunohistochemistry. In Group 3, OA biomarkers were significantly increased, whereas, IL-4, IL-10, and lubricin were significantly lower than in the other experimental groups. We hypothesize that MPA might partake in rescuing type B synoviocyte dysfunction at the early stages of OA, delaying the progression of the disease.https://www.mdpi.com/1422-0067/20/3/511osteoarthritissynoviumphysical activityinterleukinslubricin
collection DOAJ
language English
format Article
sources DOAJ
author Paola Castrogiovanni
Michelino Di Rosa
Silvia Ravalli
Alessandro Castorina
Claudia Guglielmino
Rosa Imbesi
Michele Vecchio
Filippo Drago
Marta Anna Szychlinska
Giuseppe Musumeci
spellingShingle Paola Castrogiovanni
Michelino Di Rosa
Silvia Ravalli
Alessandro Castorina
Claudia Guglielmino
Rosa Imbesi
Michele Vecchio
Filippo Drago
Marta Anna Szychlinska
Giuseppe Musumeci
Moderate Physical Activity as a Prevention Method for Knee Osteoarthritis and the Role of Synoviocytes as Biological Key
International Journal of Molecular Sciences
osteoarthritis
synovium
physical activity
interleukins
lubricin
author_facet Paola Castrogiovanni
Michelino Di Rosa
Silvia Ravalli
Alessandro Castorina
Claudia Guglielmino
Rosa Imbesi
Michele Vecchio
Filippo Drago
Marta Anna Szychlinska
Giuseppe Musumeci
author_sort Paola Castrogiovanni
title Moderate Physical Activity as a Prevention Method for Knee Osteoarthritis and the Role of Synoviocytes as Biological Key
title_short Moderate Physical Activity as a Prevention Method for Knee Osteoarthritis and the Role of Synoviocytes as Biological Key
title_full Moderate Physical Activity as a Prevention Method for Knee Osteoarthritis and the Role of Synoviocytes as Biological Key
title_fullStr Moderate Physical Activity as a Prevention Method for Knee Osteoarthritis and the Role of Synoviocytes as Biological Key
title_full_unstemmed Moderate Physical Activity as a Prevention Method for Knee Osteoarthritis and the Role of Synoviocytes as Biological Key
title_sort moderate physical activity as a prevention method for knee osteoarthritis and the role of synoviocytes as biological key
publisher MDPI AG
series International Journal of Molecular Sciences
issn 1422-0067
publishDate 2019-01-01
description The purpose of this study was to investigate the influence of moderate physical activity (MPA) on the expression of osteoarthritis (OA)-related (IL-1β, IL-6, TNF-α, MMP-13) and anti-inflammatory and chondroprotective (IL-4, IL-10, lubricin) biomarkers in the synovium of an OA-induced rat model. A total of 32 rats were divided into four groups: Control rats (Group 1); rats performing MPA (Group 2); anterior cruciate ligament transection (ACLT)-rats with OA (Group 3); and, ACLT-rats performing MPA (Group 4). Analyses were performed using Hematoxylin & Eosin (H&E) staining, histomorphometry and immunohistochemistry. In Group 3, OA biomarkers were significantly increased, whereas, IL-4, IL-10, and lubricin were significantly lower than in the other experimental groups. We hypothesize that MPA might partake in rescuing type B synoviocyte dysfunction at the early stages of OA, delaying the progression of the disease.
topic osteoarthritis
synovium
physical activity
interleukins
lubricin
url https://www.mdpi.com/1422-0067/20/3/511
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