Moderate Physical Activity as a Prevention Method for Knee Osteoarthritis and the Role of Synoviocytes as Biological Key
The purpose of this study was to investigate the influence of moderate physical activity (MPA) on the expression of osteoarthritis (OA)-related (IL-1β, IL-6, TNF-α, MMP-13) and anti-inflammatory and chondroprotective (IL-4, IL-10, lubricin) biomarkers in the synovium of an OA-induc...
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doaj-b4462d4b15524d808eda66f834c4abd52020-11-25T01:01:04ZengMDPI AGInternational Journal of Molecular Sciences1422-00672019-01-0120351110.3390/ijms20030511ijms20030511Moderate Physical Activity as a Prevention Method for Knee Osteoarthritis and the Role of Synoviocytes as Biological KeyPaola Castrogiovanni0Michelino Di Rosa1Silvia Ravalli2Alessandro Castorina3Claudia Guglielmino4Rosa Imbesi5Michele Vecchio6Filippo Drago7Marta Anna Szychlinska8Giuseppe Musumeci9Department of Biomedical and Biotechnological Sciences, Human Anatomy and Histology Section, School of Medicine, University of Catania, Via S. Sofia n°87, 95124 Catania, ItalyDepartment of Biomedical and Biotechnological Sciences, Human Anatomy and Histology Section, School of Medicine, University of Catania, Via S. Sofia n°87, 95124 Catania, ItalyDepartment of Biomedical and Biotechnological Sciences, Human Anatomy and Histology Section, School of Medicine, University of Catania, Via S. Sofia n°87, 95124 Catania, ItalySchool of Life Sciences, Faculty of Science, University of Technology Sydney, P.O. Box 123, Broadway, Sydney, NSW 2007, AustraliaDepartment of Biomedical and Biotechnological Sciences, Human Anatomy and Histology Section, School of Medicine, University of Catania, Via S. Sofia n°87, 95124 Catania, ItalyDepartment of Biomedical and Biotechnological Sciences, Human Anatomy and Histology Section, School of Medicine, University of Catania, Via S. Sofia n°87, 95124 Catania, ItalyDepartment of Biomedical and Biotechnological Sciences, Section of Pharmacology, University of Catania, via S. Sofia 67, 95123 Catania, ItalyDepartment of Biomedical and Biotechnological Sciences, Section of Pharmacology, University of Catania, via S. Sofia 67, 95123 Catania, ItalyDepartment of Biomedical and Biotechnological Sciences, Human Anatomy and Histology Section, School of Medicine, University of Catania, Via S. Sofia n°87, 95124 Catania, ItalyDepartment of Biomedical and Biotechnological Sciences, Human Anatomy and Histology Section, School of Medicine, University of Catania, Via S. Sofia n°87, 95124 Catania, ItalyThe purpose of this study was to investigate the influence of moderate physical activity (MPA) on the expression of osteoarthritis (OA)-related (IL-1β, IL-6, TNF-α, MMP-13) and anti-inflammatory and chondroprotective (IL-4, IL-10, lubricin) biomarkers in the synovium of an OA-induced rat model. A total of 32 rats were divided into four groups: Control rats (Group 1); rats performing MPA (Group 2); anterior cruciate ligament transection (ACLT)-rats with OA (Group 3); and, ACLT-rats performing MPA (Group 4). Analyses were performed using Hematoxylin & Eosin (H&E) staining, histomorphometry and immunohistochemistry. In Group 3, OA biomarkers were significantly increased, whereas, IL-4, IL-10, and lubricin were significantly lower than in the other experimental groups. We hypothesize that MPA might partake in rescuing type B synoviocyte dysfunction at the early stages of OA, delaying the progression of the disease.https://www.mdpi.com/1422-0067/20/3/511osteoarthritissynoviumphysical activityinterleukinslubricin |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Paola Castrogiovanni Michelino Di Rosa Silvia Ravalli Alessandro Castorina Claudia Guglielmino Rosa Imbesi Michele Vecchio Filippo Drago Marta Anna Szychlinska Giuseppe Musumeci |
spellingShingle |
Paola Castrogiovanni Michelino Di Rosa Silvia Ravalli Alessandro Castorina Claudia Guglielmino Rosa Imbesi Michele Vecchio Filippo Drago Marta Anna Szychlinska Giuseppe Musumeci Moderate Physical Activity as a Prevention Method for Knee Osteoarthritis and the Role of Synoviocytes as Biological Key International Journal of Molecular Sciences osteoarthritis synovium physical activity interleukins lubricin |
author_facet |
Paola Castrogiovanni Michelino Di Rosa Silvia Ravalli Alessandro Castorina Claudia Guglielmino Rosa Imbesi Michele Vecchio Filippo Drago Marta Anna Szychlinska Giuseppe Musumeci |
author_sort |
Paola Castrogiovanni |
title |
Moderate Physical Activity as a Prevention Method for Knee Osteoarthritis and the Role of Synoviocytes as Biological Key |
title_short |
Moderate Physical Activity as a Prevention Method for Knee Osteoarthritis and the Role of Synoviocytes as Biological Key |
title_full |
Moderate Physical Activity as a Prevention Method for Knee Osteoarthritis and the Role of Synoviocytes as Biological Key |
title_fullStr |
Moderate Physical Activity as a Prevention Method for Knee Osteoarthritis and the Role of Synoviocytes as Biological Key |
title_full_unstemmed |
Moderate Physical Activity as a Prevention Method for Knee Osteoarthritis and the Role of Synoviocytes as Biological Key |
title_sort |
moderate physical activity as a prevention method for knee osteoarthritis and the role of synoviocytes as biological key |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1422-0067 |
publishDate |
2019-01-01 |
description |
The purpose of this study was to investigate the influence of moderate physical activity (MPA) on the expression of osteoarthritis (OA)-related (IL-1β, IL-6, TNF-α, MMP-13) and anti-inflammatory and chondroprotective (IL-4, IL-10, lubricin) biomarkers in the synovium of an OA-induced rat model. A total of 32 rats were divided into four groups: Control rats (Group 1); rats performing MPA (Group 2); anterior cruciate ligament transection (ACLT)-rats with OA (Group 3); and, ACLT-rats performing MPA (Group 4). Analyses were performed using Hematoxylin & Eosin (H&E) staining, histomorphometry and immunohistochemistry. In Group 3, OA biomarkers were significantly increased, whereas, IL-4, IL-10, and lubricin were significantly lower than in the other experimental groups. We hypothesize that MPA might partake in rescuing type B synoviocyte dysfunction at the early stages of OA, delaying the progression of the disease. |
topic |
osteoarthritis synovium physical activity interleukins lubricin |
url |
https://www.mdpi.com/1422-0067/20/3/511 |
work_keys_str_mv |
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