Sphetcher: Spherical Thresholding Improves Sketching of Single-Cell Transcriptomic Heterogeneity

Summary: The massive size of single-cell RNA sequencing datasets often exceeds the capability of current computational analysis methods to solve routine tasks such as detection of cell types. Recently, geometric sketching was introduced as an alternative to uniform subsampling. It selects a subset o...

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Bibliographic Details
Main Authors: Van Hoan Do, Khaled Elbassioni, Stefan Canzar
Format: Article
Language:English
Published: Elsevier 2020-06-01
Series:iScience
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004220303114