Pollen allergens do not come alone: pollen associated lipid mediators (PALMS) shift the human immue systems towards a T<sub>H</sub>2-dominated response

Pollen allergens do not come alone: pollen associated lipid mediators (PALMS) shift the human immue systems towards a T<sub>H</sub>2-dominated response

<p>Abstract</p> <p>Pollen allergy is characterized by a T<sub>H</sub>2-biased immune response to pollen-derived allergens. However, pollen-exposed epithelia do not encounter pure allergen but rather a plethora of protein and non-protein substances. We demonstrated that...

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Main Authors: Gilles Stefanie, Mariani Valentina, Bryce Martina, Mueller Martin J, Ring Johannes, Behrendt Heidrun, Jakob Thilo, Traidl-Hoffmann Claudia
Format: Article
Language:English
Published: BMC 2009-10-01
Series:Allergy, Asthma & Clinical Immunology
Online Access:http://www.aacijournal.com/content/5/1/3
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spelling doaj-b437f500b71746a092219aeaaf291f0f2020-11-24T21:33:53ZengBMCAllergy, Asthma & Clinical Immunology1710-14841710-14922009-10-0151310.1186/1710-1492-5-3Pollen allergens do not come alone: pollen associated lipid mediators (PALMS) shift the human immue systems towards a T<sub>H</sub>2-dominated responseGilles StefanieMariani ValentinaBryce MartinaMueller Martin JRing JohannesBehrendt HeidrunJakob ThiloTraidl-Hoffmann Claudia<p>Abstract</p> <p>Pollen allergy is characterized by a T<sub>H</sub>2-biased immune response to pollen-derived allergens. However, pollen-exposed epithelia do not encounter pure allergen but rather a plethora of protein and non-protein substances. We demonstrated that pollen liberate lipids with chemical and functional similarities to leukotriens and prostaglandins - the pollen associated lipid mediators (PALMs). To date, two main groups of PALMs have been characterized: The immunostimulatory PALMs activating innate immune cells such as neutrophils and eosinophils, and the immunomodulatory E<sub>1</sub>-phytoprostanes blocking IL-12 production of dendritic cells, resulting in the preferential induction of T<sub>H</sub>2 responses. This article reviews our work in the field of PALMs and their effects on cells of the innate and adoptive immune system. From recent results a general picture starts to emerge in which PALMs (and possibly other pollen-associated substances) may - independently from protein allergens - propagate an overall T<sub>H</sub>2 favoring micromilieu in pollen exposed tissue of predisposed individuals.</p> http://www.aacijournal.com/content/5/1/3
collection DOAJ
language English
format Article
sources DOAJ
author Gilles Stefanie
Mariani Valentina
Bryce Martina
Mueller Martin J
Ring Johannes
Behrendt Heidrun
Jakob Thilo
Traidl-Hoffmann Claudia
spellingShingle Gilles Stefanie
Mariani Valentina
Bryce Martina
Mueller Martin J
Ring Johannes
Behrendt Heidrun
Jakob Thilo
Traidl-Hoffmann Claudia
Pollen allergens do not come alone: pollen associated lipid mediators (PALMS) shift the human immue systems towards a T<sub>H</sub>2-dominated response
Allergy, Asthma & Clinical Immunology
author_facet Gilles Stefanie
Mariani Valentina
Bryce Martina
Mueller Martin J
Ring Johannes
Behrendt Heidrun
Jakob Thilo
Traidl-Hoffmann Claudia
author_sort Gilles Stefanie
title Pollen allergens do not come alone: pollen associated lipid mediators (PALMS) shift the human immue systems towards a T<sub>H</sub>2-dominated response
title_short Pollen allergens do not come alone: pollen associated lipid mediators (PALMS) shift the human immue systems towards a T<sub>H</sub>2-dominated response
title_full Pollen allergens do not come alone: pollen associated lipid mediators (PALMS) shift the human immue systems towards a T<sub>H</sub>2-dominated response
title_fullStr Pollen allergens do not come alone: pollen associated lipid mediators (PALMS) shift the human immue systems towards a T<sub>H</sub>2-dominated response
title_full_unstemmed Pollen allergens do not come alone: pollen associated lipid mediators (PALMS) shift the human immue systems towards a T<sub>H</sub>2-dominated response
title_sort pollen allergens do not come alone: pollen associated lipid mediators (palms) shift the human immue systems towards a t<sub>h</sub>2-dominated response
publisher BMC
series Allergy, Asthma & Clinical Immunology
issn 1710-1484
1710-1492
publishDate 2009-10-01
description <p>Abstract</p> <p>Pollen allergy is characterized by a T<sub>H</sub>2-biased immune response to pollen-derived allergens. However, pollen-exposed epithelia do not encounter pure allergen but rather a plethora of protein and non-protein substances. We demonstrated that pollen liberate lipids with chemical and functional similarities to leukotriens and prostaglandins - the pollen associated lipid mediators (PALMs). To date, two main groups of PALMs have been characterized: The immunostimulatory PALMs activating innate immune cells such as neutrophils and eosinophils, and the immunomodulatory E<sub>1</sub>-phytoprostanes blocking IL-12 production of dendritic cells, resulting in the preferential induction of T<sub>H</sub>2 responses. This article reviews our work in the field of PALMs and their effects on cells of the innate and adoptive immune system. From recent results a general picture starts to emerge in which PALMs (and possibly other pollen-associated substances) may - independently from protein allergens - propagate an overall T<sub>H</sub>2 favoring micromilieu in pollen exposed tissue of predisposed individuals.</p>
url http://www.aacijournal.com/content/5/1/3
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