Fumitremorgin C Attenuates Osteoclast Formation and Function via Suppressing RANKL-Induced Signaling Pathways

Fumitremorgin C Attenuates Osteoclast Formation and Function via Suppressing RANKL-Induced Signaling Pathways

Excessive bone resorption conducted by osteoclasts is considered as the main cause of osteoclast-related bone diseases such as osteoporosis. Therefore, the suppression of excessive osteoclast formation and function is one of the strategies to treat osteoclast-related bone diseases. Fumitremorgin C (...

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Bibliographic Details
Main Authors: Yu Yuan, Kai Chen, Xi Chen, Chao Wang, Heng Qiu, Zhen Cao, Dezhi Song, Youqiang Sun, Jianmin Guo, Jennifer Tickner, Jiake Xu, Jun Zou
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Pharmacology
Subjects:
fumitremorgin C
osteoclast
osteoporosis
NFATc1
MAPK
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00238/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.00238/full

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