The kappa opioid receptor agonist U50,488H did not affect brain-stimulation reward while it elicited conditioned place aversion in mice

The kappa opioid receptor agonist U50,488H did not affect brain-stimulation reward while it elicited conditioned place aversion in mice

Abstract Objective Selective kappa opioid receptor (KOR) agonists were shown to produce a dose-dependent depression of brain-stimulation reward (BSR) in the rat intracranial self-stimulation (ICSS) tests. However, limited studies using mice produced less conclusive results. Here the effects of U50,4...

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Bibliographic Details
Main Authors: Peng Huang, Taylor A. Gentile, John W. Muschamp, Lee-Yuan Liu-Chen
Format: Article
Language:English
Published: BMC 2020-08-01
Series:BMC Research Notes
Subjects:
Kappa opioid receptor
U50,488H
Brain-stimulation reward
ICSS
Conditioned place aversion
Online Access:http://link.springer.com/article/10.1186/s13104-020-05227-7

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