Phorbol ester reduces ethanol excitation of dopaminergic neurons of the ventral tegmental area: Involvement of protein kinase C theta

Phorbol ester reduces ethanol excitation of dopaminergic neurons of the ventral tegmental area: Involvement of protein kinase C theta

Neurons of the ventral tegmental area (VTA) play a key role in the rewarding and reinforcing effects of drugs of abuse, including alcohol. Ethanol directly increases the firing rate of dopaminergic (DAergic) VTA neurons, but modulation of the firing rate of DAergic VTA neurons can be controlled by a...

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Bibliographic Details
Main Authors: Sudarat eNimitvilai, Devinder Singh Arora, Chang eYou, Maureen A. McElvain, Mark S. Brodie
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-12-01
Series:Frontiers in Integrative Neuroscience
Subjects:
Dopamine
Electrophysiology
Ethanol
Protein Kinase C
Reward
alcohol
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnint.2013.00096/full

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