Increased ATP and ADO Overflow From Sympathetic Nerve Endings and Mesentery Endothelial Cells Plus Reduced Nitric Oxide Are Involved in Diabetic Neurovascular Dysfunction

Increased ATP and ADO Overflow From Sympathetic Nerve Endings and Mesentery Endothelial Cells Plus Reduced Nitric Oxide Are Involved in Diabetic Neurovascular Dysfunction

Since the mechanism of human diabetic peripheral neuropathy and vascular disease in type 1 diabetes mellitus remains unknown, we assessed whether sympathetic transmitter overflow is altered by this disease and associated to vascular dysfunction. Diabetes was induced by streptozotocin (STZ)-treatment...

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Bibliographic Details
Main Authors: M. Verónica Donoso, M. Jesús Mascayano, Inés M. Poblete, J. Pablo Huidobro-Toro
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Pharmacology
Subjects:
Streptozotocin-induced diabetes
nucleotide release
extracellular adenosine
cultured endothelial cells
nitric oxide production
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.00546/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2018.00546/full

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