Serum RAAS molecules and their relationship with the systemic inflammatory response and target organ function in patients with severe acute pancreatitis

• Main Authors: Wei-Sheng Tang, Dong-Hua Lin, Yong-Ping Qiu
• Format: Article
• Language: English
• Published: Editorial Board of Journal of Hainan Medical University 2018-09-01
• Series: Journal of Hainan Medical University
• Subjects: Severe acute pancreatitis; Renin-angiotensin-aldosterone system; Systemic inflammatory response; Liver function; Kidney function
• Online Access: http://www.hnykdxxb.com/PDF/201809/05.pdf

Objective: To explore the relationship of renin-angiotensin-aldosterone system (RAAS) activity with the systemic inflammatory response and target organ function in patients with severe acute pancreatitis. Methods: A total of 78 patients with severe acute pancreatitis who were treated in our hospital between August 2012 and March 2016 were selected as the observation group, and 50 healthy people who underwent physical examination in our hospital during the same period were selected as the normal control group. The differences in the contents of RAAS indexes, inflammation indexes as well as liver and kidney function indexes were compared between the two groups, and Pearson test was used to evaluate the correlation between RAAS activity and illness in patients with severe acute pancreatitis. Results: Serum RAAS indexes E, Ang-Ⅱ and ALD levels of observation group were higher than those of normal control group; serum inflammation indexes IL-6, IL-8, IL-10 and CRP levels were higher than those of normal control group; serum liver function indexes ALP, γ-GT and AST levels were higher than those of normal control group; serum kidney function indexes Scr, BUN and UA levels were higher than those of normal control group. The RAAS activity of patients with severe acute pancreatitis was directly correlated with serum levels of inflammation indexes as well as liver and kidney function indexes. Conclusion: The RAAS activity increases in patients with severe acute pancreatitis, and the specific increase extent is consistent with systemic inflammatory response as well as liver and kidney function damage.