Low concentration flufenamic acid enhances osteogenic differentiation of mesenchymal stem cells and suppresses bone loss by inhibition of the NF-κB signaling pathway

Low concentration flufenamic acid enhances osteogenic differentiation of mesenchymal stem cells and suppresses bone loss by inhibition of the NF-κB signaling pathway

Abstract Background As the representative of fenamic acids, an important group of NSAIDs, flufenamic acid (FFA) has been used for anti-inflammation and analgesia in the clinic. Recently, researches have focused on the role of some members of NSAIDs in promoting osteogenesis. However, little attentio...

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Bibliographic Details
Main Authors: Xuenan Liu, Zheng Li, Hao Liu, Yuan Zhu, Dandan Xia, Siyi Wang, Ranli Gu, Weiliang Wu, Ping Zhang, Yunsong Liu, Yongsheng Zhou
Format: Article
Language:English
Published: BMC 2019-07-01
Series:Stem Cell Research & Therapy
Subjects:
Flufenamic acid
Mesenchymal stem cells
Osteogenesis
Osteoporosis
Nuclear factor-κB
Online Access:http://link.springer.com/article/10.1186/s13287-019-1321-y

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