Infection sustained by lineage B.1.1.7 of SARS-CoV-2 is characterised by longer persistence and higher viral RNA loads in nasopharyngeal swabs

Infection sustained by lineage B.1.1.7 of SARS-CoV-2 is characterised by longer persistence and higher viral RNA loads in nasopharyngeal swabs

• Following the announcement on December 2020 about the emergence of a new variant (VOC 202012/01, B.1.1.7 lineage) in the United Kingdom, a targeted surveillance was put in place in the Abruzzo region (Italy), which allowed detection of 313 persons affected by lineage B.1.1.7, up to the 20th of Feb...

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Main Authors: Paolo Calistri, Laura Amato, Ilaria Puglia, Francesca Cito, Alessandra Di Giuseppe, Maria Luisa Danzetta, Daniela Morelli, Marco Di Domenico, Marialuigia Caporale, Silvia Scialabba, Ottavio Portanti, Valentina Curini, Fabrizia Perletta, Cesare Cammà, Massimo Ancora, Giovanni Savini, Giacomo Migliorati, Nicola D’Alterio, Alessio Lorusso
Format: Article
Language:English
Published: Elsevier 2021-04-01
Series:International Journal of Infectious Diseases
Subjects:
SARS-CoV-2
Coronavirus
VOC 202012/01
lineage B.1.1.7
Abruzzo
Italy
Online Access:http://www.sciencedirect.com/science/article/pii/S1201971221002101
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spelling doaj-b3dd132bcfb849d3a500838a421a4ded2021-04-26T05:54:41ZengElsevierInternational Journal of Infectious Diseases1201-97122021-04-01105753755Infection sustained by lineage B.1.1.7 of SARS-CoV-2 is characterised by longer persistence and higher viral RNA loads in nasopharyngeal swabsPaolo Calistri0Laura Amato1Ilaria Puglia2Francesca Cito3Alessandra Di Giuseppe4Maria Luisa Danzetta5Daniela Morelli6Marco Di Domenico7Marialuigia Caporale8Silvia Scialabba9Ottavio Portanti10Valentina Curini11Fabrizia Perletta12Cesare Cammà13Massimo Ancora14Giovanni Savini15Giacomo Migliorati16Nicola D’Alterio17Alessio Lorusso18Corresponding author.; Istituto Zooprofilattico Sperimentale dell’Abruzzo e del Molise G. Caporale, 64100, Teramo, ItalyIstituto Zooprofilattico Sperimentale dell’Abruzzo e del Molise G. Caporale, 64100, Teramo, ItalyIstituto Zooprofilattico Sperimentale dell’Abruzzo e del Molise G. Caporale, 64100, Teramo, ItalyIstituto Zooprofilattico Sperimentale dell’Abruzzo e del Molise G. Caporale, 64100, Teramo, ItalyIstituto Zooprofilattico Sperimentale dell’Abruzzo e del Molise G. Caporale, 64100, Teramo, ItalyIstituto Zooprofilattico Sperimentale dell’Abruzzo e del Molise G. Caporale, 64100, Teramo, ItalyIstituto Zooprofilattico Sperimentale dell’Abruzzo e del Molise G. Caporale, 64100, Teramo, ItalyIstituto Zooprofilattico Sperimentale dell’Abruzzo e del Molise G. Caporale, 64100, Teramo, ItalyIstituto Zooprofilattico Sperimentale dell’Abruzzo e del Molise G. Caporale, 64100, Teramo, ItalyIstituto Zooprofilattico Sperimentale dell’Abruzzo e del Molise G. Caporale, 64100, Teramo, ItalyIstituto Zooprofilattico Sperimentale dell’Abruzzo e del Molise G. Caporale, 64100, Teramo, ItalyIstituto Zooprofilattico Sperimentale dell’Abruzzo e del Molise G. Caporale, 64100, Teramo, ItalyIstituto Zooprofilattico Sperimentale dell’Abruzzo e del Molise G. Caporale, 64100, Teramo, ItalyIstituto Zooprofilattico Sperimentale dell’Abruzzo e del Molise G. Caporale, 64100, Teramo, ItalyIstituto Zooprofilattico Sperimentale dell’Abruzzo e del Molise G. Caporale, 64100, Teramo, ItalyIstituto Zooprofilattico Sperimentale dell’Abruzzo e del Molise G. Caporale, 64100, Teramo, ItalyIstituto Zooprofilattico Sperimentale dell’Abruzzo e del Molise G. Caporale, 64100, Teramo, ItalyIstituto Zooprofilattico Sperimentale dell’Abruzzo e del Molise G. Caporale, 64100, Teramo, ItalyIstituto Zooprofilattico Sperimentale dell’Abruzzo e del Molise G. Caporale, 64100, Teramo, Italy• Following the announcement on December 2020 about the emergence of a new variant (VOC 202012/01, B.1.1.7 lineage) in the United Kingdom, a targeted surveillance was put in place in the Abruzzo region (Italy), which allowed detection of 313 persons affected by lineage B.1.1.7, up to the 20th of February 2021. We investigated the results of RT-PCR on nasopharyngeal swabs tested from December 2020 to February 2021 to verify any difference on the viral load and persistence between people infected by lineage B.1.1.7 and others. Statistically significant lower values of CT associated with the detection of the N protein encoding gene (CT N) were observed in persons with lineage B.1.1.7 infection (median CT N = 15.8) in comparison to those infected by other lineages (median CT N = 16.9). A significantly longer duration of the persistence of SARS-CoV-2 RNA in nasopharyngeal swabs was observed in persons with lineage B.1.1.7 infection (16 days) in comparison to those infected by other lineages (14 days).http://www.sciencedirect.com/science/article/pii/S1201971221002101SARS-CoV-2CoronavirusVOC 202012/01lineage B.1.1.7AbruzzoItaly
collection DOAJ
language English
format Article
sources DOAJ
author Paolo Calistri
Laura Amato
Ilaria Puglia
Francesca Cito
Alessandra Di Giuseppe
Maria Luisa Danzetta
Daniela Morelli
Marco Di Domenico
Marialuigia Caporale
Silvia Scialabba
Ottavio Portanti
Valentina Curini
Fabrizia Perletta
Cesare Cammà
Massimo Ancora
Giovanni Savini
Giacomo Migliorati
Nicola D’Alterio
Alessio Lorusso
spellingShingle Paolo Calistri
Laura Amato
Ilaria Puglia
Francesca Cito
Alessandra Di Giuseppe
Maria Luisa Danzetta
Daniela Morelli
Marco Di Domenico
Marialuigia Caporale
Silvia Scialabba
Ottavio Portanti
Valentina Curini
Fabrizia Perletta
Cesare Cammà
Massimo Ancora
Giovanni Savini
Giacomo Migliorati
Nicola D’Alterio
Alessio Lorusso
Infection sustained by lineage B.1.1.7 of SARS-CoV-2 is characterised by longer persistence and higher viral RNA loads in nasopharyngeal swabs
International Journal of Infectious Diseases
SARS-CoV-2
Coronavirus
VOC 202012/01
lineage B.1.1.7
Abruzzo
Italy
author_facet Paolo Calistri
Laura Amato
Ilaria Puglia
Francesca Cito
Alessandra Di Giuseppe
Maria Luisa Danzetta
Daniela Morelli
Marco Di Domenico
Marialuigia Caporale
Silvia Scialabba
Ottavio Portanti
Valentina Curini
Fabrizia Perletta
Cesare Cammà
Massimo Ancora
Giovanni Savini
Giacomo Migliorati
Nicola D’Alterio
Alessio Lorusso
author_sort Paolo Calistri
title Infection sustained by lineage B.1.1.7 of SARS-CoV-2 is characterised by longer persistence and higher viral RNA loads in nasopharyngeal swabs
title_short Infection sustained by lineage B.1.1.7 of SARS-CoV-2 is characterised by longer persistence and higher viral RNA loads in nasopharyngeal swabs
title_full Infection sustained by lineage B.1.1.7 of SARS-CoV-2 is characterised by longer persistence and higher viral RNA loads in nasopharyngeal swabs
title_fullStr Infection sustained by lineage B.1.1.7 of SARS-CoV-2 is characterised by longer persistence and higher viral RNA loads in nasopharyngeal swabs
title_full_unstemmed Infection sustained by lineage B.1.1.7 of SARS-CoV-2 is characterised by longer persistence and higher viral RNA loads in nasopharyngeal swabs
title_sort infection sustained by lineage b.1.1.7 of sars-cov-2 is characterised by longer persistence and higher viral rna loads in nasopharyngeal swabs
publisher Elsevier
series International Journal of Infectious Diseases
issn 1201-9712
publishDate 2021-04-01
description • Following the announcement on December 2020 about the emergence of a new variant (VOC 202012/01, B.1.1.7 lineage) in the United Kingdom, a targeted surveillance was put in place in the Abruzzo region (Italy), which allowed detection of 313 persons affected by lineage B.1.1.7, up to the 20th of February 2021. We investigated the results of RT-PCR on nasopharyngeal swabs tested from December 2020 to February 2021 to verify any difference on the viral load and persistence between people infected by lineage B.1.1.7 and others. Statistically significant lower values of CT associated with the detection of the N protein encoding gene (CT N) were observed in persons with lineage B.1.1.7 infection (median CT N = 15.8) in comparison to those infected by other lineages (median CT N = 16.9). A significantly longer duration of the persistence of SARS-CoV-2 RNA in nasopharyngeal swabs was observed in persons with lineage B.1.1.7 infection (16 days) in comparison to those infected by other lineages (14 days).
topic SARS-CoV-2
Coronavirus
VOC 202012/01
lineage B.1.1.7
Abruzzo
Italy
url http://www.sciencedirect.com/science/article/pii/S1201971221002101
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