Evaluation of approaches to monitor Staphylococcus aureus virulence factor expression during human disease.

Staphylococcus aureus is a versatile pathogen of medical significance, using multiple virulence factors to cause disease. A prophylactic S. aureus 4-antigen (SA4Ag) vaccine comprising capsular polysaccharide (types 5 and 8) conjugates, clumping factor A (ClfA) and manganese transporter C (MntC) is u...

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Main Authors: Wouter Rozemeijer, Pamela Fink, Eduardo Rojas, C Hal Jones, Danka Pavliakova, Peter Giardina, Ellen Murphy, Paul Liberator, Qin Jiang, Douglas Girgenti, Remco P H Peters, Paul H M Savelkoul, Kathrin U Jansen, Annaliesa S Anderson, Jan Kluytmans
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4342157?pdf=render