Molecular Mechanisms and Genome-Wide Aspects of PPAR Subtype Specific Transactivation

Molecular Mechanisms and Genome-Wide Aspects of PPAR Subtype Specific Transactivation

The peroxisome proliferator-activated receptors (PPARs) are central regulators of fat metabolism, energy homeostasis, proliferation, and inflammation. The three PPAR subtypes, PPAR𝛼, 𝛽/𝛿, and 𝛾 activate overlapping but also very different target gene programs. This review summarizes the insights int...

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Main Authors: Anne Bugge, Susanne Mandrup
Format: Article
Language:English
Published: Hindawi Limited 2010-01-01
Series:PPAR Research
Online Access:http://dx.doi.org/10.1155/2010/169506
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spelling doaj-b3d07965a5294564b29c259cea52a9392020-11-24T23:04:29ZengHindawi LimitedPPAR Research1687-47571687-47652010-01-01201010.1155/2010/169506169506Molecular Mechanisms and Genome-Wide Aspects of PPAR Subtype Specific TransactivationAnne Bugge0Susanne Mandrup1Department of Biochemistry and Molecular Biology, University of Southern Denmark, 5230 Odense, DenmarkDepartment of Biochemistry and Molecular Biology, University of Southern Denmark, 5230 Odense, DenmarkThe peroxisome proliferator-activated receptors (PPARs) are central regulators of fat metabolism, energy homeostasis, proliferation, and inflammation. The three PPAR subtypes, PPAR𝛼, 𝛽/𝛿, and 𝛾 activate overlapping but also very different target gene programs. This review summarizes the insights into PPAR subtype-specific transactivation provided by genome-wide studies and discusses the recent advances in the understanding of the molecular mechanisms underlying PPAR subtype specificity with special focus on the regulatory role of AF-1.http://dx.doi.org/10.1155/2010/169506
collection DOAJ
language English
format Article
sources DOAJ
author Anne Bugge
Susanne Mandrup
spellingShingle Anne Bugge
Susanne Mandrup
Molecular Mechanisms and Genome-Wide Aspects of PPAR Subtype Specific Transactivation
PPAR Research
author_facet Anne Bugge
Susanne Mandrup
author_sort Anne Bugge
title Molecular Mechanisms and Genome-Wide Aspects of PPAR Subtype Specific Transactivation
title_short Molecular Mechanisms and Genome-Wide Aspects of PPAR Subtype Specific Transactivation
title_full Molecular Mechanisms and Genome-Wide Aspects of PPAR Subtype Specific Transactivation
title_fullStr Molecular Mechanisms and Genome-Wide Aspects of PPAR Subtype Specific Transactivation
title_full_unstemmed Molecular Mechanisms and Genome-Wide Aspects of PPAR Subtype Specific Transactivation
title_sort molecular mechanisms and genome-wide aspects of ppar subtype specific transactivation
publisher Hindawi Limited
series PPAR Research
issn 1687-4757
1687-4765
publishDate 2010-01-01
description The peroxisome proliferator-activated receptors (PPARs) are central regulators of fat metabolism, energy homeostasis, proliferation, and inflammation. The three PPAR subtypes, PPAR𝛼, 𝛽/𝛿, and 𝛾 activate overlapping but also very different target gene programs. This review summarizes the insights into PPAR subtype-specific transactivation provided by genome-wide studies and discusses the recent advances in the understanding of the molecular mechanisms underlying PPAR subtype specificity with special focus on the regulatory role of AF-1.
url http://dx.doi.org/10.1155/2010/169506
work_keys_str_mv AT annebugge molecularmechanismsandgenomewideaspectsofpparsubtypespecifictransactivation
AT susannemandrup molecularmechanismsandgenomewideaspectsofpparsubtypespecifictransactivation
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