How to draw the line in biomedical research

The use of the least squares method to calculate the best-fitting line through a two-dimensional scatter plot typically requires the user to assume that one of the variables depends on the other. However, in many cases the relationship between the two variables is more complex, and it is not valid t...

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Bibliographic Details
Main Authors: Lisa Huang, Amir Rattner, Han Liu, Jeremy Nathans
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2013-03-01
Series:eLife
Subjects:
Online Access:https://elifesciences.org/articles/00638
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spelling doaj-b3cb598889434a92ac52a04556dfcc7c2021-05-04T21:29:27ZengeLife Sciences Publications LtdeLife2050-084X2013-03-01210.7554/eLife.00638How to draw the line in biomedical researchLisa Huang0Amir Rattner1Han Liu2Jeremy Nathans3Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, United StatesDepartment of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, United StatesDepartment of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, United StatesDepartment of Molecular Biology and Genetics, the Department of Neuroscience, the Department of Ophthalmology, Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, United StatesThe use of the least squares method to calculate the best-fitting line through a two-dimensional scatter plot typically requires the user to assume that one of the variables depends on the other. However, in many cases the relationship between the two variables is more complex, and it is not valid to say that one variable is independent and the other is dependent. When analysing such data researchers should consider plotting the three regression lines that can be calculated for any two-dimensional scatter plot.https://elifesciences.org/articles/00638Tutorialstatisticpublishing
collection DOAJ
language English
format Article
sources DOAJ
author Lisa Huang
Amir Rattner
Han Liu
Jeremy Nathans
spellingShingle Lisa Huang
Amir Rattner
Han Liu
Jeremy Nathans
How to draw the line in biomedical research
eLife
Tutorial
statistic
publishing
author_facet Lisa Huang
Amir Rattner
Han Liu
Jeremy Nathans
author_sort Lisa Huang
title How to draw the line in biomedical research
title_short How to draw the line in biomedical research
title_full How to draw the line in biomedical research
title_fullStr How to draw the line in biomedical research
title_full_unstemmed How to draw the line in biomedical research
title_sort how to draw the line in biomedical research
publisher eLife Sciences Publications Ltd
series eLife
issn 2050-084X
publishDate 2013-03-01
description The use of the least squares method to calculate the best-fitting line through a two-dimensional scatter plot typically requires the user to assume that one of the variables depends on the other. However, in many cases the relationship between the two variables is more complex, and it is not valid to say that one variable is independent and the other is dependent. When analysing such data researchers should consider plotting the three regression lines that can be calculated for any two-dimensional scatter plot.
topic Tutorial
statistic
publishing
url https://elifesciences.org/articles/00638
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