Wnt-regulated lncRNA discovery enhanced by in vivo identification and CRISPRi functional validation

Wnt-regulated lncRNA discovery enhanced by in vivo identification and CRISPRi functional validation

Abstract Background Wnt signaling is an evolutionarily conserved developmental pathway that is frequently hyperactivated in cancer. While multiple protein-coding genes regulated by Wnt signaling are known, the functional lncRNAs regulated by Wnt signaling have not been systematically characterized....

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Bibliographic Details
Main Authors: Shiyang Liu, Nathan Harmston, Trudy Lee Glaser, Yunka Wong, Zheng Zhong, Babita Madan, David M. Virshup, Enrico Petretto
Format: Article
Language:English
Published: BMC 2020-10-01
Series:Genome Medicine
Subjects:
Functional lncRNAs
Wnt signaling
Cancer
CRISPRi screen
Online Access:http://link.springer.com/article/10.1186/s13073-020-00788-5

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