Tumor-Associated Macrophage Status in Cancer Treatment
Tumor-associated macrophages (TAMs) represent the most abundant innate immune cells in tumors. TAMs, exhibiting anti-inflammatory phenotype, are key players in cancer progression, metastasis and resistance to therapy. A high TAM infiltration is generally associated with poor prognosis, but macrophag...
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MDPI AG
2020-07-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/12/7/1987 |
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doaj-b3c528c43879412e99028fc640fd66a42020-11-25T03:11:23ZengMDPI AGCancers2072-66942020-07-01121987198710.3390/cancers12071987Tumor-Associated Macrophage Status in Cancer TreatmentAnna Maria Malfitano0Simona Pisanti1Fabiana Napolitano2Sarah Di Somma3Rosanna Martinelli4Giuseppe Portella5Department of Translational Medical Sciences, University of Naples Federico II, 80131 Naples, ItalyDepartment of Medicine, Surgery and Dentistry “Scuola Medica Salernitana”, University of Salerno, Via Salvador Allende, Baronissi, 84081 Salerno, ItalyDepartment of Translational Medical Sciences, University of Naples Federico II, 80131 Naples, ItalyDepartment of Translational Medical Sciences, University of Naples Federico II, 80131 Naples, ItalyDepartment of Medicine, Surgery and Dentistry “Scuola Medica Salernitana”, University of Salerno, Via Salvador Allende, Baronissi, 84081 Salerno, ItalyDepartment of Translational Medical Sciences, University of Naples Federico II, 80131 Naples, ItalyTumor-associated macrophages (TAMs) represent the most abundant innate immune cells in tumors. TAMs, exhibiting anti-inflammatory phenotype, are key players in cancer progression, metastasis and resistance to therapy. A high TAM infiltration is generally associated with poor prognosis, but macrophages are highly plastic cells that can adopt either proinflammatory/antitumor or anti-inflammatory/protumor features in response to tumor microenvironment stimuli. In the context of cancer therapy, many anticancer therapeutics, apart from their direct effect on tumor cells, display different effects on TAM activation status and density. In this review, we aim to evaluate the indirect effects of anticancer therapies in the modulation of TAM phenotypes and pro/antitumor activity.https://www.mdpi.com/2072-6694/12/7/1987tumor-associated macrophageschemotherapyradiotherapyimmune-checkpoint blocking therapyoncolytic virusvirotherapy |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Anna Maria Malfitano Simona Pisanti Fabiana Napolitano Sarah Di Somma Rosanna Martinelli Giuseppe Portella |
| spellingShingle |
Anna Maria Malfitano Simona Pisanti Fabiana Napolitano Sarah Di Somma Rosanna Martinelli Giuseppe Portella Tumor-Associated Macrophage Status in Cancer Treatment Cancers tumor-associated macrophages chemotherapy radiotherapy immune-checkpoint blocking therapy oncolytic virus virotherapy |
| author_facet |
Anna Maria Malfitano Simona Pisanti Fabiana Napolitano Sarah Di Somma Rosanna Martinelli Giuseppe Portella |
| author_sort |
Anna Maria Malfitano |
| title |
Tumor-Associated Macrophage Status in Cancer Treatment |
| title_short |
Tumor-Associated Macrophage Status in Cancer Treatment |
| title_full |
Tumor-Associated Macrophage Status in Cancer Treatment |
| title_fullStr |
Tumor-Associated Macrophage Status in Cancer Treatment |
| title_full_unstemmed |
Tumor-Associated Macrophage Status in Cancer Treatment |
| title_sort |
tumor-associated macrophage status in cancer treatment |
| publisher |
MDPI AG |
| series |
Cancers |
| issn |
2072-6694 |
| publishDate |
2020-07-01 |
| description |
Tumor-associated macrophages (TAMs) represent the most abundant innate immune cells in tumors. TAMs, exhibiting anti-inflammatory phenotype, are key players in cancer progression, metastasis and resistance to therapy. A high TAM infiltration is generally associated with poor prognosis, but macrophages are highly plastic cells that can adopt either proinflammatory/antitumor or anti-inflammatory/protumor features in response to tumor microenvironment stimuli. In the context of cancer therapy, many anticancer therapeutics, apart from their direct effect on tumor cells, display different effects on TAM activation status and density. In this review, we aim to evaluate the indirect effects of anticancer therapies in the modulation of TAM phenotypes and pro/antitumor activity. |
| topic |
tumor-associated macrophages chemotherapy radiotherapy immune-checkpoint blocking therapy oncolytic virus virotherapy |
| url |
https://www.mdpi.com/2072-6694/12/7/1987 |
| work_keys_str_mv |
AT annamariamalfitano tumorassociatedmacrophagestatusincancertreatment AT simonapisanti tumorassociatedmacrophagestatusincancertreatment AT fabiananapolitano tumorassociatedmacrophagestatusincancertreatment AT sarahdisomma tumorassociatedmacrophagestatusincancertreatment AT rosannamartinelli tumorassociatedmacrophagestatusincancertreatment AT giuseppeportella tumorassociatedmacrophagestatusincancertreatment |
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1724654470030163968 |