Discovery of human cell selective effector molecules using single cell multiplexed activity metabolomics

Bioactive metabolites from plant and microbial extracts hold therapeutic potential. Here, the authors combine untargeted metabolomic arrays with flow cytometry-based single cell response profiling and identify metabolites with cell subset-specific activities in the bone marrow from an AML patient.

Bibliographic Details
Main Authors:	David C. Earl, P. Brent Ferrell, Nalin Leelatian, Jordan T. Froese, Benjamin J. Reisman, Jonathan M. Irish, Brian O. Bachmann
Format:	Article
Language:	English
Published:	Nature Publishing Group 2018-01-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-017-02470-8

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spelling	doaj-b3bcc8bdbb794beeb2a498e7912fa5bb2021-05-11T10:22:17ZengNature Publishing GroupNature Communications2041-17232018-01-019111210.1038/s41467-017-02470-8Discovery of human cell selective effector molecules using single cell multiplexed activity metabolomicsDavid C. Earl0P. Brent Ferrell1Nalin Leelatian2Jordan T. Froese3Benjamin J. Reisman4Jonathan M. Irish5Brian O. Bachmann6Department of Chemistry, Vanderbilt UniversityDepartment of Medicine, Vanderbilt University Medical CenterDepartment of Cell and Developmental Biology, Vanderbilt UniversityDepartment of Chemistry, Vanderbilt UniversityDepartment of Chemistry, Vanderbilt UniversityDepartment of Cell and Developmental Biology, Vanderbilt UniversityDepartment of Chemistry, Vanderbilt UniversityBioactive metabolites from plant and microbial extracts hold therapeutic potential. Here, the authors combine untargeted metabolomic arrays with flow cytometry-based single cell response profiling and identify metabolites with cell subset-specific activities in the bone marrow from an AML patient.https://doi.org/10.1038/s41467-017-02470-8
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	David C. Earl P. Brent Ferrell Nalin Leelatian Jordan T. Froese Benjamin J. Reisman Jonathan M. Irish Brian O. Bachmann
spellingShingle	David C. Earl P. Brent Ferrell Nalin Leelatian Jordan T. Froese Benjamin J. Reisman Jonathan M. Irish Brian O. Bachmann Discovery of human cell selective effector molecules using single cell multiplexed activity metabolomics Nature Communications
author_facet	David C. Earl P. Brent Ferrell Nalin Leelatian Jordan T. Froese Benjamin J. Reisman Jonathan M. Irish Brian O. Bachmann
author_sort	David C. Earl
title	Discovery of human cell selective effector molecules using single cell multiplexed activity metabolomics
title_short	Discovery of human cell selective effector molecules using single cell multiplexed activity metabolomics
title_full	Discovery of human cell selective effector molecules using single cell multiplexed activity metabolomics
title_fullStr	Discovery of human cell selective effector molecules using single cell multiplexed activity metabolomics
title_full_unstemmed	Discovery of human cell selective effector molecules using single cell multiplexed activity metabolomics
title_sort	discovery of human cell selective effector molecules using single cell multiplexed activity metabolomics
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2018-01-01
description	Bioactive metabolites from plant and microbial extracts hold therapeutic potential. Here, the authors combine untargeted metabolomic arrays with flow cytometry-based single cell response profiling and identify metabolites with cell subset-specific activities in the bone marrow from an AML patient.
url	https://doi.org/10.1038/s41467-017-02470-8
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Discovery of human cell selective effector molecules using single cell multiplexed activity metabolomics

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