Sulfarotene, a synthetic retinoid, overcomes stemness and sorafenib resistance of hepatocellular carcinoma via suppressing SOS2-RAS pathway

Sulfarotene, a synthetic retinoid, overcomes stemness and sorafenib resistance of hepatocellular carcinoma via suppressing SOS2-RAS pathway

Abstract Background Recurrent hepatocellular carcinoma (HCC) shows strong resistance to sorafenib, and the tumor-repopulating cells (TRCs) with cancer stem cell-like properties are considered a driver for its high recurrent rate and drug resistance. Methods Suppression of TRCs may thus be an effecti...

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Bibliographic Details
Main Authors: Feng Qi, Wenxing Qin, Yao Zhang, Yongde Luo, Bing Niu, Quanlin An, Biwei Yang, Keqing Shi, Zhijie Yu, Junwei Chen, Xin Cao, Jinglin Xia
Format: Article
Language:English
Published: BMC 2021-09-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Hepatocellular carcinoma
Tumor-repopulating cells
Retinoid
Sulfarotene
SOS2
Online Access:https://doi.org/10.1186/s13046-021-02085-4

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