Tumour-draining axillary lymph nodes in patients with large and locally advanced breast cancers undergoing neoadjuvant chemotherapy (NAC): the crucial contribution of immune cells (effector, regulatory) and cytokines (Th1, Th2) to immune-mediated tumour cell death induced by NAC

Tumour-draining axillary lymph nodes in patients with large and locally advanced breast cancers undergoing neoadjuvant chemotherapy (NAC): the crucial contribution of immune cells (effector, regulatory) and cytokines (Th1, Th2) to immune-mediated tumour cell death induced by NAC

Abstract Background The tumour microenvironment consists of malignant cells, stroma and immune cells. In women with large and locally advanced breast cancers (LLABCs) undergoing neoadjuvant chemotherapy (NAC), tumour-infiltrating lymphocytes (TILs), various subsets (effector, regulatory) and cytokin...

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Bibliographic Details
Main Authors: Viriya Kaewkangsadan, Chandan Verma, Jennifer M. Eremin, Gerard Cowley, Mohammad Ilyas, Oleg Eremin
Format: Article
Language:English
Published: BMC 2018-02-01
Series:BMC Cancer
Subjects:
Axillary lymph node
Breast cancer
Neoadjuvant chemotherapy
Tumour microenvironment
Tumour-infiltrating lymphocyte subsets
Cytokines
Online Access:http://link.springer.com/article/10.1186/s12885-018-4044-z

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