Design, Synthesis and Biological Evaluation of Novel Primaquine-Cinnamic Acid Conjugates of the Amide and Acylsemicarbazide Type

Design, Synthesis and Biological Evaluation of Novel Primaquine-Cinnamic Acid Conjugates of the Amide and Acylsemicarbazide Type

In this paper design and synthesis of a scaffold comprising primaquine (PQ) motif and cinnamic acid derivatives (CADs) bound directly (compounds 3a–k) or via a spacer (compounds 7a–k) are reported. In the first series of compounds, PQ and various CADs were connected by amide bonds and in the second...

Full description

Bibliographic Details
Main Authors: Kristina Pavić, Ivana Perković, Petra Gilja, Filip Kozlina, Katja Ester, Marijeta Kralj, Dominique Schols, Dimitra Hadjipavlou-Litina, Eleni Pontiki, Branka Zorc
Format: Article
Language:English
Published: MDPI AG 2016-11-01
Series:Molecules
Subjects:
primaquine
cinnamic acid derivative
conjugate
cytostatic activity
antiviral activity
antioxidative activity
Online Access:http://www.mdpi.com/1420-3049/21/12/1629

Internet

http://www.mdpi.com/1420-3049/21/12/1629

Similar Items