ADAR1-mediated regulation of melanoma invasion

ADAR1-mediated regulation of melanoma invasion

In metastatic melanoma, ADAR1 is downregulated, facilitating proliferation. Here, the authors show an ADAR1-dependent and RNA-editing-independent regulation of melanoma invasion mediated by ITGB3 expression, which can be reversed when ITGB3 is blocked.

Bibliographic Details
Main Authors: Yael Nemlich, Erez Nissim Baruch, Michal Judith Besser, Einav Shoshan, Menashe Bar-Eli, Liat Anafi, Iris Barshack, Jacob Schachter, Rona Ortenberg, Gal Markel
Format: Article
Language:English
Published: Nature Publishing Group 2018-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-04600-2
Description
Summary:In metastatic melanoma, ADAR1 is downregulated, facilitating proliferation. Here, the authors show an ADAR1-dependent and RNA-editing-independent regulation of melanoma invasion mediated by ITGB3 expression, which can be reversed when ITGB3 is blocked.
ISSN:2041-1723

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