Mechanisms of translocation of ER chaperones to the cell surface and immunomodulatory roles in cancer and autoimmunity

Mechanisms of translocation of ER chaperones to the cell surface and immunomodulatory roles in cancer and autoimmunity

Endoplasmic reticulum (ER) chaperones (e.g. calreticulin, heat shock proteins and isomerases) perform a multitude of functions within the ER. However, many of these chaperones can translocate to the cytosol and eventually the surface of cells, particularly during ER stress induced by e.g. drugs, UV...

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Bibliographic Details
Main Authors: Valerie R. Wiersma, Marek eMichalak, Trefa M. Abdullah, Edwin eBremer, Paul eEggleton
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-01-01
Series:Frontiers in Oncology
Subjects:
Calreticulin
er stress
Immunogenic cell death
post-translational modification
Damage Associated Molecular Patterns (DAMPs)
Online Access:http://journal.frontiersin.org/Journal/10.3389/fonc.2015.00007/full

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