Microchannelled alkylated chitosan sponge to treat noncompressible hemorrhages and facilitate wound healing

Microchannelled alkylated chitosan sponge to treat noncompressible hemorrhages and facilitate wound healing

Developing effective treatments for noncompressible hemorrhages remains a challenge. Here the authors engineer alkylated chitosan sponges with highly interconnective microchannels and demonstrate anti-infective activity, as well as higher pro-coagulant, hemostatic and wound healing capacities compar...

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Main Authors: Xinchen Du, Le Wu, Hongyu Yan, Zhuyan Jiang, Shilin Li, Wen Li, Yanli Bai, Hongjun Wang, Zhaojun Cheng, Deling Kong, Lianyong Wang, Meifeng Zhu
Format: Article
Language:English
Published: Nature Publishing Group 2021-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-24972-2
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spelling doaj-b37ce626c8a64381bec7cf7063c5061a2021-08-08T11:36:38ZengNature Publishing GroupNature Communications2041-17232021-08-0112111610.1038/s41467-021-24972-2Microchannelled alkylated chitosan sponge to treat noncompressible hemorrhages and facilitate wound healingXinchen Du0Le Wu1Hongyu Yan2Zhuyan Jiang3Shilin Li4Wen Li5Yanli Bai6Hongjun Wang7Zhaojun Cheng8Deling Kong9Lianyong Wang10Meifeng Zhu11College of Life Sciences, Key Laboratory of Bioactive Materials (Ministry of Education),Tianjin Center Hospital of Obstetrics and Gynecology, State Key Laboratory of Medicine Chemical Biology, Nankai UniversityCollege of Life Sciences, Key Laboratory of Bioactive Materials (Ministry of Education),Tianjin Center Hospital of Obstetrics and Gynecology, State Key Laboratory of Medicine Chemical Biology, Nankai UniversityCollege of Life Sciences, Key Laboratory of Bioactive Materials (Ministry of Education),Tianjin Center Hospital of Obstetrics and Gynecology, State Key Laboratory of Medicine Chemical Biology, Nankai UniversityDepartment of Orthopedics, The Second Hospital of Tianjin Medical UniversityCollege of Life Sciences, Key Laboratory of Bioactive Materials (Ministry of Education),Tianjin Center Hospital of Obstetrics and Gynecology, State Key Laboratory of Medicine Chemical Biology, Nankai UniversityCollege of Life Sciences, Key Laboratory of Bioactive Materials (Ministry of Education),Tianjin Center Hospital of Obstetrics and Gynecology, State Key Laboratory of Medicine Chemical Biology, Nankai UniversityCollege of Life Sciences, Key Laboratory of Bioactive Materials (Ministry of Education),Tianjin Center Hospital of Obstetrics and Gynecology, State Key Laboratory of Medicine Chemical Biology, Nankai UniversityDepartment of Biomedical Engineering, Stevens Institute of TechnologyShenzhen Traditional Chinese Medicine HospitalCollege of Life Sciences, Key Laboratory of Bioactive Materials (Ministry of Education),Tianjin Center Hospital of Obstetrics and Gynecology, State Key Laboratory of Medicine Chemical Biology, Nankai UniversityCollege of Life Sciences, Key Laboratory of Bioactive Materials (Ministry of Education),Tianjin Center Hospital of Obstetrics and Gynecology, State Key Laboratory of Medicine Chemical Biology, Nankai UniversityCollege of Life Sciences, Key Laboratory of Bioactive Materials (Ministry of Education),Tianjin Center Hospital of Obstetrics and Gynecology, State Key Laboratory of Medicine Chemical Biology, Nankai UniversityDeveloping effective treatments for noncompressible hemorrhages remains a challenge. Here the authors engineer alkylated chitosan sponges with highly interconnective microchannels and demonstrate anti-infective activity, as well as higher pro-coagulant, hemostatic and wound healing capacities compared to clinically-used materials in rat and pig liver models.https://doi.org/10.1038/s41467-021-24972-2
collection DOAJ
language English
format Article
sources DOAJ
author Xinchen Du
Le Wu
Hongyu Yan
Zhuyan Jiang
Shilin Li
Wen Li
Yanli Bai
Hongjun Wang
Zhaojun Cheng
Deling Kong
Lianyong Wang
Meifeng Zhu
spellingShingle Xinchen Du
Le Wu
Hongyu Yan
Zhuyan Jiang
Shilin Li
Wen Li
Yanli Bai
Hongjun Wang
Zhaojun Cheng
Deling Kong
Lianyong Wang
Meifeng Zhu
Microchannelled alkylated chitosan sponge to treat noncompressible hemorrhages and facilitate wound healing
Nature Communications
author_facet Xinchen Du
Le Wu
Hongyu Yan
Zhuyan Jiang
Shilin Li
Wen Li
Yanli Bai
Hongjun Wang
Zhaojun Cheng
Deling Kong
Lianyong Wang
Meifeng Zhu
author_sort Xinchen Du
title Microchannelled alkylated chitosan sponge to treat noncompressible hemorrhages and facilitate wound healing
title_short Microchannelled alkylated chitosan sponge to treat noncompressible hemorrhages and facilitate wound healing
title_full Microchannelled alkylated chitosan sponge to treat noncompressible hemorrhages and facilitate wound healing
title_fullStr Microchannelled alkylated chitosan sponge to treat noncompressible hemorrhages and facilitate wound healing
title_full_unstemmed Microchannelled alkylated chitosan sponge to treat noncompressible hemorrhages and facilitate wound healing
title_sort microchannelled alkylated chitosan sponge to treat noncompressible hemorrhages and facilitate wound healing
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2021-08-01
description Developing effective treatments for noncompressible hemorrhages remains a challenge. Here the authors engineer alkylated chitosan sponges with highly interconnective microchannels and demonstrate anti-infective activity, as well as higher pro-coagulant, hemostatic and wound healing capacities compared to clinically-used materials in rat and pig liver models.
url https://doi.org/10.1038/s41467-021-24972-2
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