Identification of Leishmania major UDP-Sugar Pyrophosphorylase Inhibitors Using Biosensor-Based Small Molecule Fragment Library Screening

Identification of Leishmania major UDP-Sugar Pyrophosphorylase Inhibitors Using Biosensor-Based Small Molecule Fragment Library Screening

Leishmaniasis is a neglected disease that is caused by different species of the protozoan parasite Leishmania, and it currently affects 12 million people worldwide. The antileishmanial therapeutic arsenal remains very limited in number and efficacy, and there is no vaccine for this parasitic disease...

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Bibliographic Details
Main Authors: Ohm Prakash, Jana Führing, John Post, Sharon M. Shepherd, Thomas C. Eadsforth, David Gray, Roman Fedorov, Françoise H. Routier
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:Molecules
Subjects:
UDP-sugar pyrophosphorylase
allosteric inhibitor
inhibitor scaffold
library screen
Online Access:http://www.mdpi.com/1420-3049/24/5/996

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