Subject identification using edge-centric functional connectivity

Group-level studies do not capture individual differences in network organization, an important prerequisite for understanding neural substrates shaping behavior and for developing interventions in clinical conditions. Recent studies have employed ‘fingerprinting’ analyses on functional connectivity...

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Main Authors: Youngheun Jo, Joshua Faskowitz, Farnaz Zamani Esfahlani, Olaf Sporns, Richard F. Betzel
Format: Article
Language:English
Published: Elsevier 2021-09-01
Series:NeuroImage
Online Access:http://www.sciencedirect.com/science/article/pii/S105381192100481X
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spelling doaj-b3777d2b9ebe406696c9006a89e3435d2021-07-25T04:41:58ZengElsevierNeuroImage1095-95722021-09-01238118204Subject identification using edge-centric functional connectivityYoungheun Jo0Joshua Faskowitz1Farnaz Zamani Esfahlani2Olaf Sporns3Richard F. Betzel4Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN 47405, USA; Cognitive Science Program, Indiana University, Bloomington, IN 47405, USADepartment of Psychological and Brain Sciences, Indiana University, Bloomington, IN 47405, USA; Cognitive Science Program, Indiana University, Bloomington, IN 47405, USADepartment of Psychological and Brain Sciences, Indiana University, Bloomington, IN 47405, USADepartment of Psychological and Brain Sciences, Indiana University, Bloomington, IN 47405, USA; Cognitive Science Program, Indiana University, Bloomington, IN 47405, USA; Program in Neuroscience, Indiana University, Bloomington, IN 47405, USA; Network Science Institute, Indiana University, Bloomington, IN 47405, USACorresponding author at: Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN 47405, USA.; Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN 47405, USA; Cognitive Science Program, Indiana University, Bloomington, IN 47405, USA; Program in Neuroscience, Indiana University, Bloomington, IN 47405, USA; Network Science Institute, Indiana University, Bloomington, IN 47405, USAGroup-level studies do not capture individual differences in network organization, an important prerequisite for understanding neural substrates shaping behavior and for developing interventions in clinical conditions. Recent studies have employed ‘fingerprinting’ analyses on functional connectivity to identify subjects’ idiosyncratic features. Here, we develop a complementary approach based on an edge-centric model of functional connectivity, which focuses on the co-fluctuations of edges. We first show whole-brain edge functional connectivity (eFC) to be a robust substrate that improves identifiability over nodal FC (nFC) across different datasets and parcellations. Next, we characterize subjects’ identifiability at different spatial scales, from single nodes to the level of functional systems and clusters using k-means clustering. Across spatial scales, we find that heteromodal brain regions exhibit consistently greater identifiability than unimodal, sensorimotor, and limbic regions. Lastly, we show that identifiability can be further improved by reconstructing eFC using specific subsets of its principal components. In summary, our results highlight the utility of the edge-centric network model for capturing meaningful subject-specific features and sets the stage for future investigations into individual differences using edge-centric models.http://www.sciencedirect.com/science/article/pii/S105381192100481X
collection DOAJ
language English
format Article
sources DOAJ
author Youngheun Jo
Joshua Faskowitz
Farnaz Zamani Esfahlani
Olaf Sporns
Richard F. Betzel
spellingShingle Youngheun Jo
Joshua Faskowitz
Farnaz Zamani Esfahlani
Olaf Sporns
Richard F. Betzel
Subject identification using edge-centric functional connectivity
NeuroImage
author_facet Youngheun Jo
Joshua Faskowitz
Farnaz Zamani Esfahlani
Olaf Sporns
Richard F. Betzel
author_sort Youngheun Jo
title Subject identification using edge-centric functional connectivity
title_short Subject identification using edge-centric functional connectivity
title_full Subject identification using edge-centric functional connectivity
title_fullStr Subject identification using edge-centric functional connectivity
title_full_unstemmed Subject identification using edge-centric functional connectivity
title_sort subject identification using edge-centric functional connectivity
publisher Elsevier
series NeuroImage
issn 1095-9572
publishDate 2021-09-01
description Group-level studies do not capture individual differences in network organization, an important prerequisite for understanding neural substrates shaping behavior and for developing interventions in clinical conditions. Recent studies have employed ‘fingerprinting’ analyses on functional connectivity to identify subjects’ idiosyncratic features. Here, we develop a complementary approach based on an edge-centric model of functional connectivity, which focuses on the co-fluctuations of edges. We first show whole-brain edge functional connectivity (eFC) to be a robust substrate that improves identifiability over nodal FC (nFC) across different datasets and parcellations. Next, we characterize subjects’ identifiability at different spatial scales, from single nodes to the level of functional systems and clusters using k-means clustering. Across spatial scales, we find that heteromodal brain regions exhibit consistently greater identifiability than unimodal, sensorimotor, and limbic regions. Lastly, we show that identifiability can be further improved by reconstructing eFC using specific subsets of its principal components. In summary, our results highlight the utility of the edge-centric network model for capturing meaningful subject-specific features and sets the stage for future investigations into individual differences using edge-centric models.
url http://www.sciencedirect.com/science/article/pii/S105381192100481X
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