Identification, synthesis, and characterization of potential genotoxic impurities of sildenafil citrate drug substance

Identification, synthesis, and characterization of potential genotoxic impurities of sildenafil citrate drug substance

Abstract Background Sildenafil is a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specifil phophodiesterase type 5 (PDE5). Sildenafil enhances the effect of nitric oxide by inhibiting phosphodiesterase type 5, which is responsible for the degradation of cGMP in the corpus cavernosum....

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Bibliographic Details
Main Authors: P. Rajesh Reddy, Sivanadh Musunuri, D. Rama Sekhara Reddy, V. Subrahmanyam Chittala, V. N. S. Murthy P, K. Krishnamohan
Format: Article
Language:English
Published: SpringerOpen 2020-11-01
Series:Future Journal of Pharmaceutical Sciences
Subjects:
Sildenafil
Genotoxic impurities
Sulfonyl esters
Synthesis
Characterization
Online Access:http://link.springer.com/article/10.1186/s43094-020-00095-1

Internet

http://link.springer.com/article/10.1186/s43094-020-00095-1

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