Chemically Induced Hypoxia Enhances miRNA Functions in Breast Cancer

Chemically Induced Hypoxia Enhances miRNA Functions in Breast Cancer

In aggressively growing tumors, hypoxia induces HIF-1α expression promoting angiogenesis. Previously, we have shown that overexpression of oncogenic microRNAs (miRNAs, miRs) miR526b/miR655 in poorly metastatic breast cancer cell lines promotes aggressive cancer phenotypes in vitro and in vivo. Addit...

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Bibliographic Details
Main Authors: Emma Gervin, Bonita Shin, Reid Opperman, Mackenzie Cullen, Riley Feser, Sujit Maiti, Mousumi Majumder
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Cancers
Subjects:
Breast cancer
Hypoxia inducible factor 1-alpha (HIF-1α)
MicroRNA (miRNA)
miR526b
miR655
Oxidative stress
Online Access:https://www.mdpi.com/2072-6694/12/8/2008

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