Immune-Mediated Fever in the Dog. Occurrence of Antinuclear Antibodies, Rheumatoid Factor, Tumor Necrosis Factor and Interleukin-6 in Serum

• Main Authors: Moen Torolf, Hanssen I, Bohnhorst Øvrebø
• Format: Article
• Language: English
• Published: BMC 2002-09-01
• Series: Acta Veterinaria Scandinavica
• Subjects: dog; immune; fever; antinuclear antibodies; rheumatoid factor; tumor necrosis factor; interleukin-6.
• Online Access: http://www.actavetscand.com/content/43/3/165
• ISSN: 1751-0147

<p/> <p>Contents of antinuclear antibodies (ANA), rheumatoid factor (RF), tumor necrosis factor (TNF-α) and interleukin-6 (IL-6) were measured in serum from 20 dogs with immune-mediated fever. Seven out of 20 patients were ANA positive, 1 out of 20 was positive to antibodies against extractable nuclear antigens (ENA), 1 out of 20 was positive to antibodies against deoxynucleoproteins (DNP), 2 out of 13 were RF positive and none out of 20 patients had antibodies against native DNA in the serum. TNF-α was not detected in any serum of 15 dogs with immune-mediated fever, while 10 out of 13 presented with elevated IL-6. The results varied between patients, but the IL-6 level was high in most of them. This indicate a role for IL-6 in the pathogenesis of immune-mediated fever in most cases.</p>