Assessment of changes in the brca2 and p53 genes in breast invasive ductal carcinoma in northeast Brazil

Assessment of changes in the brca2 and p53 genes in breast invasive ductal carcinoma in northeast Brazil

BACKGROUND: BRCA protein interacts with at least 13 different proteins that have been implicated with cancer susceptibility and loss of BRCA function is correlated to sensitivity to DNA crosslinking agents in preclinical models. RESULTS: BRCA2 methylation frequency was 44%, p53 Pro22 allele frequenc...

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Bibliographic Details
Main Authors: Eduardo AVF Ramalho, João LQ Silva-Filho, Marina FS Cartaxo, Carmelita BL Cavalcanti, Moacyr JBM Rêgo, Maria BM Oliveira, Eduardo IC Beltrão
Format: Article
Language:English
Published: BMC 2014-01-01
Series:Biological Research
Subjects:
Breast cancer
Epigenetics
Metastasis
Methylation
Polymorphism
Online Access:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602014000100003&lng=en&tlng=en

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