Identification of Breast Cancer-Associated Lipids in Scalp Hair

A correlation between the presence of breast cancer and a change in the synchrotron-generated X-ray diffraction (XRD) pattern of hair has been reported in several publications by different groups, and on average XRD-based assays detect around 75% of breast cancer patients in blinded studies. To date...

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Main Authors:	Dharmica A.H. Mistry, Joseph Haklani, Peter W. French
Format:	Article
Language:	English
Published:	SAGE Publishing 2012-01-01
Series:	Breast Cancer: Basic and Clinical Research
Online Access:	https://doi.org/10.4137/BCBCR.S9607

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spelling	doaj-b357f11aa013431593dcf9298d2615cb2020-11-25T03:34:53ZengSAGE PublishingBreast Cancer: Basic and Clinical Research1178-22342012-01-01610.4137/BCBCR.S9607Identification of Breast Cancer-Associated Lipids in Scalp HairDharmica A.H. Mistry0Joseph Haklani1Peter W. French2SBC Research, Level 12, 97–99 Bathurst Street, Sydney, New South Wales, Australia.Fermiscan Ltd., Sydney New South Wales, Australia.SBC Research, Level 12, 97–99 Bathurst Street, Sydney, New South Wales, Australia.A correlation between the presence of breast cancer and a change in the synchrotron-generated X-ray diffraction (XRD) pattern of hair has been reported in several publications by different groups, and on average XRD-based assays detect around 75% of breast cancer patients in blinded studies. To date, the molecular mechanisms leading to this alteration are largely unknown. We have determined that the alteration is likely to be due to the presence of one or more breast cancer-associated phospholipids. Further characterization of these lipids could be used to develop a novel, sensitive and specific screening test for breast cancer, based on hair initially, and potentially extendable to other biological samples.https://doi.org/10.4137/BCBCR.S9607
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Dharmica A.H. Mistry Joseph Haklani Peter W. French
spellingShingle	Dharmica A.H. Mistry Joseph Haklani Peter W. French Identification of Breast Cancer-Associated Lipids in Scalp Hair Breast Cancer: Basic and Clinical Research
author_facet	Dharmica A.H. Mistry Joseph Haklani Peter W. French
author_sort	Dharmica A.H. Mistry
title	Identification of Breast Cancer-Associated Lipids in Scalp Hair
title_short	Identification of Breast Cancer-Associated Lipids in Scalp Hair
title_full	Identification of Breast Cancer-Associated Lipids in Scalp Hair
title_fullStr	Identification of Breast Cancer-Associated Lipids in Scalp Hair
title_full_unstemmed	Identification of Breast Cancer-Associated Lipids in Scalp Hair
title_sort	identification of breast cancer-associated lipids in scalp hair
publisher	SAGE Publishing
series	Breast Cancer: Basic and Clinical Research
issn	1178-2234
publishDate	2012-01-01
description	A correlation between the presence of breast cancer and a change in the synchrotron-generated X-ray diffraction (XRD) pattern of hair has been reported in several publications by different groups, and on average XRD-based assays detect around 75% of breast cancer patients in blinded studies. To date, the molecular mechanisms leading to this alteration are largely unknown. We have determined that the alteration is likely to be due to the presence of one or more breast cancer-associated phospholipids. Further characterization of these lipids could be used to develop a novel, sensitive and specific screening test for breast cancer, based on hair initially, and potentially extendable to other biological samples.
url	https://doi.org/10.4137/BCBCR.S9607
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Identification of Breast Cancer-Associated Lipids in Scalp Hair

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