Gut microbiota-mediated lysophosphatidylcholine generation promotes colitis in intestinal epithelium-specific Fut2 deficiency

Gut microbiota-mediated lysophosphatidylcholine generation promotes colitis in intestinal epithelium-specific Fut2 deficiency

Abstract Background and aims Previous study disclosed Fucosyltransferase 2 (Fut2) gene as a IBD risk locus. This study aimed to explore the mechanism of Fut2 in IBD susceptibility and to propose a new strategy for the treatment of IBD. Methods Intestinal epithelium-specific Fut2 knockout (Fut2 △IEC)...

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Bibliographic Details
Main Authors: Xuelian Tang, Weijun Wang, Gaichao Hong, Caihan Duan, Siran Zhu, Yuen Tian, Chaoqun Han, Wei Qian, Rong Lin, Xiaohua Hou
Format: Article
Language:English
Published: BMC 2021-03-01
Series:Journal of Biomedical Science
Subjects:
Fut2
IBD
Gut microbiota
LPC
Online Access:https://doi.org/10.1186/s12929-021-00711-z

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