Particle-mediated Intravenous Delivery of Antigen mRNA Results in Strong Antigen-specific T-cell Responses Despite the Induction of Type I Interferon

Particle-mediated Intravenous Delivery of Antigen mRNA Results in Strong Antigen-specific T-cell Responses Despite the Induction of Type I Interferon

Cancer vaccines based on mRNA are extensively studied. The fragile nature of mRNA has instigated research into carriers that can protect it from ribonucleases and as such enable its systemic use. However, carrier-mediated delivery of mRNA has been linked to production of type I interferon (IFN) that...

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Bibliographic Details
Main Authors: Katrijn Broos, Kevin Van der Jeught, Janik Puttemans, Cleo Goyvaerts, Carlo Heirman, Heleen Dewitte, Rein Verbeke, Ine Lentacker, Kris Thielemans, Karine Breckpot
Format: Article
Language:English
Published: Elsevier 2016-01-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
cytotoxic T lymphocyte
immunotherapy
liposome
mRNA
particle
type I interferon
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253117300525

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